Anti Trypanosomal Activity of Crude Extracts Of Endophytic Fungi (Acremonium Sp.) Isolated From Ocimum Gratisimum Leaf.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 6
Abstract
Trypanosomiasis is a parasitic disease that affects both humans and animals. It is caused by the parasitic protozoan, trypanosome,. The development of a vaccine for the treatment of the disease is becoming increasingly complicated due to the problem of antigenic variation, thus the reliance on chemotherapeutic agents to control the disease.Drugs derived from natural sources play an important role in the avoidance and treatment of human diseases.Recent studies have shown a variety of health properties of endophytic fungal extract. The ethylaceted and the methanolic extraction were carried out. The bioactive fungal extract was tested invitro on Trypanosoma brucei brucei (federe strain). The in vitro assessment of Acremonium sp extract show graded trypanocidal activity at different concentrations with LC50of0.204, as indicated in the table of percentile. It also shows that as the concentration Increase the mortality also increases.
Authors and Affiliations
Malala A. U. , Dayyiba A. M. , Machina I. B
Keywords
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