ANTI-TYROSINASE AND CYTOTOXICITY ACTIVITIES OF CURCUMIN-METAL COMPLEXES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: The objective of this study is investigating the potential of curcumin metal complexes in pharmaceutical and cosmetic products.Methods: Curcumin was complexed with five divalent transition metals (Zn(II), Cu(II), Fe(II), Mn(II), and Mg(II)) and then investigated for their anti-tyrosinase activity and their mode of inhibition against mushroom tyrosinase and cytotoxicity against KB and MCF-7 cell lines.Results: The tyrosinase inhibition of curcumin increased in the presence of Mn (II) and Zn (II); however, the activity was reduced after complexingwith Cu (II), Fe (II), and Mg (II). Curcumin manganese complex (curcumin-Mn) exhibited the highest potent anti-tyrosinase activity with classical noncompetitive inhibitor which showed the inhibition constant (KI)of 3.57 µg/mL(7.58µg/mL for free curcumin). For the cytotoxicity against KB and MCF7 cell lines, free curcumin showed cytotoxicity against both KB (IC50 9.58 mg/mL) and MCF7 (13.86 mg/mL) cancer cell lines;  whereas, it was found to be lower in the metal complexes.Conclusion: This study suggests a potential use of the curcumin-Mn and Zn as a depigmentation agent in cosmetic products.
Authors and Affiliations
Nisakorn Saewan, Anongnuch Thakam, Ampa Jintaisong, Krisada Kittigowitana
Keywords
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