Anti-ulcer Mechanisms of L-lysine in Male Wistar Rats
Journal Title: Journal of Applied Life Sciences International - Year 2017, Vol 12, Issue 4
Abstract
L-lysine is an essential amino acid found in most protein food sources, in particular high-protein foods such as eggs, meat, soybean, milk and fish. This amino acid has been reported to have an indirect antioxidant property. Antioxidants are known to have gastroprotective property. This study examined the effect of L-lysine pre-treatment on indomethacin induced ulceration in male Wistar rats. Fifty male Wistar rats were used for this study and were randomly divided into two study groups of twenty five (25) animals each. The first sub-group was used for the anti-ulcer studies; antioxidant enzymes (SOD, CAT, and MDA), Nitric oxide, parietal cell count, and the mean ulcer score, while the second sub-group was used for the gastric mucus secretion study. Each sub-group was divided into five groups with five animals per group namely: Control, Omeprazole (20 mg/kg), L-lysine (100 mg/kg, 200 mg/kg and 400 mg/kg). The results showed that l-lysine pre-treatment significantly increased SOD activity and reduced MDA levels but with no significant change in catalase activity. NO levels in the treated groups were significantly higher than in the control. Gastric mucus secretion was significantly increased and the parietal cell count significantly reduced in L-lysine pre-treated animals. The findings from this study reveal that l-lysine supplement has some anti-ulcer properties which might be mediated through increased antioxidant enzymes, increase gastric mucus secretion and inhibition of parietal cell synthesis. This will be beneficial in the treatment of peptic ulcer.
Authors and Affiliations
Chukwu J. Okonkwo, Francis S. Oluwole, Ayobami Dare
Keywords
Related Articles
- EP ID EP317982
- DOI 10.9734/JALSI/2017/34276
- Views 119
- Downloads 0
Zingiber officinale, a Phytogenic Feed Additive on Haematological and Serum Biochemical Indices of Yankasa Rams
Aims: The study was carried out to evaluate Zingiber officinale supplementation on haematology and serum biochemical properties of Yankasa rams. Methodology: Four complete experimental diets were formulated with graded...
Association between Malnutrition and Immunoglobulin G Responses to Crude Asexual P. falciparum schizont Lysates in Children Attending Ishiara Hospital, Embu County, Kenya
Aim: The aim of this study was to determine levels of Plasmodium falciparum parasitaemia in children and relationship between IgG responses against the parasite and nutritional status of children. Study Design: Cross sec...
Nutritional Evaluation of Marula (Sclerocarya birrea) Seed Cake as a Protein Supplement in Dairy Meal
Aims: To investigate the nutritional properties of Marula (Sclerocarya birrea) Seed Cake as a protein supplement in dairy cattle ration. Study Design: Experimental design used was a completely randomized design (CRD). Pl...
Effect of Food Processing on Reduction of Pesticide Residues in Vegetables
Pesticides are widely used in food production to increase food security despite the fact that they can have negative health effects on consumers. Pesticide residues have been found in various fruits and vegetables; both...
Prevalence of Bacterial, Trichomonas and Candidal Vaginosis among Females in Angwan-Fulani, Palladan in Zaria, Nigeria
Aims: This study was conducted to determine the prevalence of agents of vaginitis among females in Angwan-Fulani, Palladan-Zaria. Study Design: Experimental design used was a completely randomized design (CRD). Place and...