Anti-urease Activity of Mimusops elengi Linn (Sapotaceae)
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 6, Issue 4
Abstract
Aim: Mimusops elengi L. (Sapotaceae) commonly known as Bakul is a small to large evergreen tree found all over the different parts of the world. Literature survey showed no reports on the anti urease activity of the flowers and leaves of Mimusops elengi. The present study was therefore envisaged to evaluate the anti urease activity of the methanolic extracts (MFE and MLE) of M. elengi. Study Design: Assessment of anti urease activity and total phenolic contents. Methodology: For the determination of total phenolic content of M. elengi extracts (MFE and MLE) the reaction mixture contained 50% Folin-Ciocalteu reagent (0.5 mL), 20% (w/v) sodium carbonate solution (2.5 mL), and gallic acid solution (1, 2.5, 5, 10, 25, 50, 100 g/ml) or sample extracts (1.0 mL). Urease inhibition activity was determined by mixing Urease (Jack bean) method was employed for urease inhibition activity. Results: From the standard calibration curve of gallic acid the total phenolic contents in extracts (MFE and MLE) was found to be 7.50.28 mg/g, 96.84.6 mg/g. Urease inhibitory activity of M. elengi extracts (MFE and MLE) was comparable with standard Thiourea. The percentage urease inhibition of Thiourea was found to be 98.2%, IC50 88.2 ± 0.01 g/ml. The maximum urease inhibitory activity was shown by the leaves extract (MLE) i. e, 77.9% (IC50 62.1±1.20 g/ml) while methanolic extract of flower (MFE) produced 47.6% urease inhibition activity. The total phenolic contents in both methanolic extracts (MFE and MLE) was found to be 7.50.28 mg/g, 96.84.6 mg/g respectively. Conclusion: It is, therefore, concluded that this plant can be a sources to isolate some natural urease inhibitory agents.
Authors and Affiliations
Hina Zahid, Ghazala H. Rizwani, Arfa Kamil, Huma Shareef, Sabiha Tasleem, Ajmal Khan
Keywords
Related Articles
- EP ID EP350147
- DOI 10.9734/EJMP/2015/12240
- Views 131
- Downloads 0
Evaluation of Antidiabetic and the Effect of Methanolic Leaf Extract of Jatropha curcas on Some Biochemical Parameters in Alloxan-induced Diabetic Male Albino Rats
Aims: The study evaluates the antidiabetic, and the effect of methanolic leaf extract of Jatropha curcas on some biochemical parameters in alloxan-induced diabetic male albino rats (Wistar strain). Place and Duration of...
Andrographis paniculata Nees (Kalmegh): A Review on Its Antibacterial Activities and Phytocompounds
Aims: To study the number of researches performed in the area of antibacterial activities and phytocompounds of Andrographis paniculata. Study Design: The present scenario of increasing rate of multi-drug resistance to...
An Overview of Ethiopian Traditional Medicinal Plants Used for Cancer Treatment
Traditional medicine plays a significant role in the healthcare of the majority of the people in developing countries, including Ethiopia, and medicinal plants provide valuable contribution to this practice. Emerging evi...
Unearthing the Medicinal Properties of Tillandsia recurvata (Ball Moss): A Mini Review
Background: More than half of traditional medicines are of natural origin and research has shown that these are associated with fewer side effects than the synthetic ones, since less than 10% of the 350,000 identified pl...
Ex vivo and In vivo Antioxidant Related Effects of Zingiber officinale Roscoe (Ginger) Extracts in Humans
Aims: To investigate antioxidant related effects of Zingiber officinale Roscoe (ginger) in humans. Study Design: Venous blood from healthy volunteers was used to conduct ex vivo experiments. For in vivo study, nine heal...