Antiatherogenic effect of quercetin is mediated by proteasome inhibition in the aorta and circulating leukocytes.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 4
Abstract
Quercetin, a plant-derived flavonoid, has attracted considerable attention as promising compound for heart disease prevention and therapy. It has been linked to decreased mortality from heart disease and decreased incidence of stroke. Here, we report new data showing the angioprotective properties of quercetin mediated by its effect on proteasomal proteolysis. This study was designed to investigate the ability of quercetin to modulate proteasomal activity in a rabbit model of cholesterol-induced atherosclerosis. First, we show proteasomal trypsin-like (TL) activity increased up to 2.4-fold, chymotrypsin-like (CTL) activity increased by up to 43% and peptidyl-glutamyl peptide-hydrolyzing (PGPH) activity increased by up to 10% after 8 weeks of a cholesterol-rich diet. A single intravenous injection of the water-soluble form of quercetin (Corvitin) significantly decreased proteasomal TL activity 1.85-fold in monocytes, and decreased the CTL and PGPH activities more than 2-fold in polymorphonuclear leukocytes (PMNL) after 2 h. Prolonged administration (1 month) of Corvitin to animals following a cholesterol-rich diet significantly decreased all types of proteolytic proteasome activities both in tissues and in circulating leukocytes and was associated with the reduction of atherosclerotic lesion areas in the aorta. Additionally, the pharmacological form of quercetin (Quertin) was shown to have an antiatherogenic effect and an ability to inhibit proteasome activities.
Authors and Affiliations
Denis Pashevin, Lesya Tumanovska, Victor Dosenko, Vasyl Nagibin, Veronika Gurianova, Alexey Moibenko
Keywords
Related Articles
- EP ID EP160782
- DOI -
- Views 93
- Downloads 0
Central interaction between physostigmine and histamine during yawning in rats.
In this study, the effects of intraperitoneal (ip) injection of physostigmine, subcutaneous (sc) injection of atropine, and intracerebroventricular (icv) injections of histamine, chlorpheniramine (H(1)-receptor antagonis...
2-Chloro-N(6)-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model.
This study examines the anticonvulsant profile of interactions between 2-chloro-N(6)-cyclopentyladenosine (CCPA, a selective adenosine A(1) receptor agonist) and four conventional antiepileptic drugs (AEDs: carbamazepine...
Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes.
The main objective of the study was to develop an alternative non-genetic rat model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60 g) were randomly divided into six groups, namely: Norma...
Pharmacology of dimethyl sulfoxide in cardiac and CNS damage.
The pharmacological effects of dimethyl sulfoxide (DMSO) administration include some desirable properties that may be useful in the treatment of medical disorders resulting in tissue injury and compromised organ systems....
Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility.
Infertility is a common problem affecting one in six couples, and in 30% of infertile couples, the male factor is a major cause due to defective sperm quality. P-glycoprotein (P-gp), a product of the MDR1 (ABCB1) gene, m...