Antibacterial Activity of Astrotrichiliaparvifolia(J.-F. Leroy &Lescot)Leaf Extracts (Meliaceae)
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
This work was designed to assess the antibacterial activity of Astrotrichiliaparvifolia, a Malagasyendemic Meliaceae used in traditional medicine.Ethyl acetate and methanol extracts from leaves were tested against pathogenic germs including 4 Gram(+) and 4Gram (-) bacteriausing disk diffusion and micro dilution methods.At 1000µg/disk, both extracts showedan inhibitory activityagainstGram(+)but not Gram (- )bacteria. Bacillus cereus was the most sensitive germ with an Inhibition Zone Diameter (IZD) of 13mm and 14mm with ethyl acetate and methanol extracts respectively and Streptococcus pneumoniae the less sensitive with an IZD of 9mm and 10mm. With Minimum Inhibitory Concentration (MIC) and Minimum bactericidal concentration (MBC) values ranging from 230 to 930μg/ml, the two extracts displayed significant activity on Staphylococcus aureus, Bacillus cereus andStreptococcus pyogenes. Theyhad the same level of activity againstStreptococcus pyogenes but the methanol extract was more efficient against Staphylococcus aureus and Bacillus cereus.They hada bactericidal actionagainst thosebacteria. Antimicrobial activity might be due to saponins, flavonoids, triterpenes, polyphenols, tannins and leucoanthocyanins present in leaves.This work demonstrated for the first time the antibacterial activity of theAstrotrichiliagenus. Keywords:
Authors and Affiliations
Rojovola Rasolofonantenaina, Rado Rasolomampianina, HerivonyOnja Andriambeloson, LovarintsoaJudicael Randriamampianina, Laurence Ralamboranto, Victor Louis Jeannodaz
Keywords
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