ANTIBACTERIAL ACTIVITY OF THREE PLANT EXTRACTS USED IN NIGERIA FOLKLORIC MEDICINE AGAINST HOSPITAL ISOLATES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND METHICILLIN-SENSITIVE STAPHYLOCOCCUS AUREUS (MSSA) 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3

Abstract

 Staphylococcus aureus is a species of bacterium commonly found on the skin and/or in the noses of healthy people. Although it is usually harmless at these sites, it may occasionally get into the body (eg through breaks in the skin such as abrasions, cuts, wounds, surgical incisions or indwelling catheters) and cause infections. These infections may be mild (eg pimples or boils) or serious (eg infection of the bloodstream, bones or joints). It is one of the important bacteria as a potential pathogen specifically for nosocomial infections. Interest in plants with antimicrobial properties has revived as a result of current problems associated with the use of antibiotics.Hexane, ethylacetate, methanol and water extracts from 3 different plant species, Jatropha curcas, Piliostigma thonningii and Hyptis suaveolens used in Nigeria as popular medicine for the treatment of several ailments of microbial and non-microbial origin were evaluated for potential antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) using agar dilution method. Results revealed that there were no significant differences in the % susceptibility to MRSA and MSSA between the standard drugs and the different plant extracts using different extracting solvents (P>0.05). All the extracts of the 3 plants were effective on MRSA except water extract of Jatropha curcas and Piliostigma thonningii. Hexane extract from P. thonningii was inhibitory to 100% of both MRSA and MSSA isolates followed by ethyl acetate extract of J. curcas 61% of MSSA, ethyl acetate extract of P. thonningii on 38% of MRSA, methanol extract of J. curcas on 33% of both MSSA and MRSA and the least activity was with water extract of H. suaveolens on 17% of both MSSA and MRSA; no activity was observed with water extract of J. curcas. Hexane extract of P.thonningii was the only extract found in this study to inhibit the growth of both MRSA and MSSA. The phytochemical screening of crude extracts revealed the presence of tannins, phenols, sterol, and saponin in J curcas; saponin, tannin, flavonoid, phenols and alkaloid was observed in H. suaveolens, while P. thonningii extracts consist of flavonoid, phenol, sterol, tannin, saponin and cardiac glycosides. The presence of these bioactive components in the present study may be responsible for inhibition of the isolates.

Authors and Affiliations

SY Daniyan , M Galadima , IJah UJJ , Odama LE

Keywords

Related Articles

SYNTHESIS, DOCKING STUDIES AND ANTIOXIDANT ACTIVITY OF LINEAR TETRAPEPTIDE FAYV 

The linear tetrapeptide Phe-Ala-Tyr-Val (FAYV) was designed based on docking results using Schrodinger Software tool. The tetrapeptide was conveniently synthesized by solution phase peptide synthesis using Dicyclohexylca...

DEVELOPMENT AND VALIDATION OF RP-HPLC ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF PHENTERMINE AND TOPIRAMATE IN PURE AND ITS PHARMACEUTICAL DOSAGE FORMS  

Developing a single analytical method for estimation of individual drug from a multidrug composition is a very challenging task. A simple, rapid, precise, and reliable simultaneous stability indicating RP - HPLC method...

CUMIN (CUMINUM CYMINUM L.; UMBELLIFERAE) CULTIVATION IN WEST BENGAL PLAINS, KALYANI, NADIA  

Cumin (Cuminum cyminum L.; Family: Umbelliferae) is a seed spice of commercial importance as well as it is a potential medicinal herb with immense therapeutic uses not withstanding its significance in health food formula...

EMULGEL: A COMPREHENSIVE REVIEW ON THE RECENT ADVANCES IN TOPICAL DRUG DELIVERY  

Emulgel has emerged as a promising drug delivery system for the delivery of hydrophobic drugs. When gel and emulsion are used in combined form they are referred as Emulgel. Emulsion in gel have emerged as one of the most...

EVALUATION OF WOUND HEALING ACTIVITY OF HELIOTROPIUM INDICUM LEAVES 

Present study is about the wound healing activity of ethanol and aqueous extracts of H.indicum leaves in wistar rats. Three wound models viz incision, excision and dead space wound were used in this study. The biophysica...

Download PDF file
  • EP ID EP140209
  • DOI -
  • Views 171
  • Downloads 0

How To Cite

SY Daniyan, M Galadima, IJah UJJ, Odama LE (2011). ANTIBACTERIAL ACTIVITY OF THREE PLANT EXTRACTS USED IN NIGERIA FOLKLORIC MEDICINE AGAINST HOSPITAL ISOLATES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND METHICILLIN-SENSITIVE STAPHYLOCOCCUS AUREUS (MSSA) . International Research Journal of Pharmacy (IRJP), 2(3), 74-81. https://europub.co.uk./articles/-A-140209