ANTIBIOTIC QUALITY MONITORING: DETERMINATION OF COTRIMOXAZOLE USED IN TREATMENT IN ANTIBIOTIC RESISTANCE CASES AT TASIKMALAYA CITY HEALTH CENTER, INDONESIA
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 2
Abstract
Objective: Cotrimoxazole is a broad spectrum anti-microbial used in the management of Acute Respiratory Infection (ARIs) disease. The good quality of antibiotics greatly determines the effectiveness and success in therapy. The level of an antibiotic is one of the quality parameters that must meet the requirements stated in the United State Pharmacopeia (USP). Methods: The cotrimoxazole antibiotic used in the treatment of ARIs was obtained from the health center of the City of Tasikmalaya. The determination of cotrimoxazole was carried out using HPLC instruments, using validation parameters linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ). Results: The test results showed that the levels of trimethoprim and sulphamethoxazole that were used to meet the requirements that exist in the USP grading 90.88 % and 102.30 %, and the validation parameters that meet the requirements, correlation coefficient of 0.9982, recovery percent of 99.01 %, precision 0.125 %, LOD 0.8359 μg/mL and LOQ 2.533 μg/mL. Conclusions: The test results showed that the levels of cotrimoxazole antibiotics that are used to meet the requirements that exist in the USP.
Authors and Affiliations
Danni Ramdhani
Keywords
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