Antibiotic Susceptibility Pattern of Pyogenic Infectious Diseases in a Teaching Hospital of Tripura
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
India has one of the highest burdens of bacterial diseases in the world and thus, antibiotics have a significant role in reducing mortality and morbidity in the country. Area specific studies are required in monitoring the trend of type of pathogens and their sensitivity pattern in systemic infection. This study gives an account of isolation of bacterial pathogens from various clinical specimens and their antibiogram, in this geographical area of North East India. Various clinical samples like urine, sputum, body fluids, pus and blood sent to Microbiology laboratory were processed for isolation of the organisms and subsequent antibiotic susceptibility test. A total of 154 patients participated in the study, of which 113(73.4%) samples were culture positive. Female patients were significantly higher than males. The mean age has been calculated to be 55.2 years with standard deviation of 18.46. The culture proven cases of urinary tract infection were 69 (61.1%), followed by lower respiratory tract infection to be 49 (43.4%). The highest number of isolate was E. coli (26%) followed by Klebsiella pneumoniae (18.2%). There were 88(77.9%) numbers of isolates of Gram negative bacilli. The sensitivity pattern of antibiotics to Gram negative bacilli shows that, most of the isolates were sensitive to Imipenem (93 %) followed by Piperacillin Tazobactum (85.1%), Amikacin (80.5%) and Meropenem (80.5%). There were 25 isolates representing Gram positive cocci, of which Staphylococcus aureus was the predominant isolate followed by Enterococcus faecalise. The antibiotics which were observed to be more sensitive to the isolates were Vancomycin (96%), Linezolid (88%), Gentamicin (88%) and Cotrimoxazole (76%). Multiple drug resistance has been observed in 19 (16.8%) isolates. The present data represents the effective first line antibiotic agents to be Amikacin and Cefoperazone sulbactum in this geographical area.
Authors and Affiliations
Sangita Choudhury, Dipankar Prakas Bhaumik, Jayanta Debnath
Keywords
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