Anticancer activity of plant-derived proteins against human tumor cell lines
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 1
Abstract
Cancer today represents a significant public health problem worldwide and the challenge is to produce cost-effective drugs. Recently, a surge of progress was achieved in the area of cytotoxic proteins. Eleven crude protein extracts, from different plants, were tested for anticancer activities against four cell lines; HepG2, Caco-2, HEP-2, and HeLa cells using MTT assay. Out of the tested extracts, Momordica charantia showed the highest anticancer potency of all tested protein fractions that is superior than that of 5-FU. Furthermore, its anticancer activity was characterised by the selective growth inhibitory effect on epithelial derived cell lines, HeLa, Caco-2 andHEP-2, but not in HepG2. On the other hand, Lactuca sativa protein fraction exhibited a potent and a selective anticancer activity against HepG2 that could be used as a lead for further investigations in the area of liver cancer therapy. In conclusion, although these findings are very promising and may open an avenue towards an economic plant-based selective anticancer drug, the exact chemical nature of active fractions remains to be fully explored and elucidated.
Authors and Affiliations
Sara A. Abozaid| Departments of Pharmacognosy Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt, Hany N. Baraka| Departments of Pharmacognosy Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt, Ahmed S. Ibrahim| Biochemistry Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt, Ahmed A. Gohar| Departments of Pharmacognosy Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt, Farid A. Badria*| Departments of Pharmacognosy Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt
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