Anticancer, antioxidant and analgesic properties of croton Caudatus Geisel leaf extracts
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2015, Vol 7, Issue 9
Abstract
Croton caudatus Geisel is a traditional anticancer medicinal herb of the people of Mizoram, India. In the present study, the in vivo and in vitro anticancer potentials, antioxidant and analgesic properties of C. caudatus leaf extracts were evaluated. Phytochemical constituents of its methanol and aqueous extracts were also analyzed. Methanol (CC-Meth) and aqueous (CC-Aq) extracts exhibited potent anticancer activity in vivo (%ILS ̴ 92.5%) while in vitro cytotoxic activity was noted only with the aqueous extract. CC-Aq extract exhibited an IC50 value 28.36 µg/ml in vitro. The two extracts also significantly reduce acetic acid and formalin-induced pains in mice. The analgesic activity in both the first and second phases of formalin-induced pain test suggested that the extracts have both analgesic and anti-inflammatory properties. The aqueous extract showed significant DPPH and nitric oxide radical scavenging potentials. Results of preliminary phytochemical screening of aqueous extract of C. caudatus revealed the presence of alkaloids in larger amount and flavonoids, saponins, tannins and cardiac glycosides in lesser amount. The phytochemical constituents and antioxidant properties of the plant extract may be an important contributory factors involved in the anticancer and analgesic activities of aqueous extract of C. caudatus leaf.
Authors and Affiliations
Gabriel Rosangkima Ganesh Chandra Jagetia
Keywords
Related Articles
- EP ID EP405985
- DOI -
- Views 152
- Downloads 0
Comparing the use of body mass index (BMI) and triceps skin fold thickness (SFT) in determining the prevalence of underweight, overweight and obesity among primary school pupils in Abakaliki metropolis of Ebonyi state, South East Nigeria
Background: Body mass index (BMI) and triceps skinfold thickness thickness (SFT) are assessment tools for underweight, a major health problem in developing countries as well as emerging obesity and overweight. Objective...
Urinary tract infection by Trichosporon asahii – a case report from South India
Trichosporon asahii belongs to class Basidiomycetes and is known to cause both superficial and deep seated infections of increasing morbidity and mortality in both immunocompetent and immunodeficient hosts. Urinary tract...
ODONTOGENIC KERATOCYST IN THE MAXILLARY SINUS
Odontogenic Keratocyst (OKC) are defined as epithelial cell lined cysts. Most of these Odontogenic cyst are defined by their history. (OKC) is an entity from the Odontogenicyst, have potential Aggressive behavior and hig...
A rare case of aneurysmal bone cyst of the calcaneum
Aneurysmal bone cyst (ABC) is a benign solitary bone lesion of unknown etiology. ABCs mainly occur in the long bones but only rarely in the bones of the feet. Few cases of ABC involving the calcaneum have been reported.W...
An observational study on incidence and severity of intravenous medication errors in south Indian Hospital
Aim: Intravenous medication errors are frequent events. They are associated with considerable harm, but little is known about their causes. The objective of the study was to find out the IV medication errors in medical...