ANTICHOLINESTERASE ACTIVITY OF OCTA PEPTIDES RELATED TO HUMAN HISTATIN 8: IN-SILICO DRUG DESIGN AND IN-VITRO
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 6
Abstract
Objective: To evaluate the octapeptides related to human histatin 8 by in-silico and in-vitro studies.Method: Schrodinger, LLC and Ellman’s method.Results: The compound HH1 and HH2 was found to be potent docking score of −9.494 and −7.401 against acetylcholinesterase (AChE) enzyme. The IC50 value of HH1 and HH2 was found to be 0.39±0.28 and 0.78±0.15 μg/mL. However, these compounds are shown to be highly effective as compared with the control AChE inhibitor donepezil (0.065±0.0050 μg/mL).Conclusion: In-silico docking study was conducted for the designed octapeptides related to human histatin 8 against AChE enzyme shows significance binding affinity toward HH1 and HH2 peptides and the AChE inhibitory activity of octapeptides shown to be a highly potent inhibitor as compared with control donepezil.
Authors and Affiliations
Pandurangan Perumal, Mani Vasudevan, Sridevi Chigurupati, Manikandan Selvaraj
Keywords
Related Articles
- EP ID EP605311
- DOI 10.22159/ajpcr.2017.v10i6.17697
- Views 131
- Downloads 0
A PRELIMINARY OBSERVATION ON AN EXPLICIT ANTIMICROBIAL ACTION OF MANGROVE PLANTS ON PSEUDOMONAS AERUGINOSA
Objectives: Due to emerging drug-resistant microorganisms throughout the world, newer antimicrobial agents should be looked for. Plants are enriched with different bioactive chemicals. In this study, we searched antibact...
NEUROIMMUNO MODULATION BY VESTIBULAR STIMULATION IN COLD WATER SWIMMING STRESS INDUCED WISTAR ALBINO RATS
ABSTRACTObjectives: We hypothesized that vestibular stimulation prevents stress-induced suppression of immunity by inhibiting the stress axes and to testthis hypothesis total leucocyte count, differential leucocyte count...
PHYTOCHEMICAL EVALUATION, GC-MS ANALYSIS OF PHYTOACTIVE COMPOUNDS, AND ANTIBACTERIAL ACTIVITY STUDIES FROM LINUM USITATISSIMUM
Objective: The flaxseed or linseed (Linum usitatissimum) is a minor oil seed belonging to the family Linaceae and genus Linum, which has been used as a precious nutritional food grain and folklore medicine in human diets...
ZN(II)/AU(I) AND ZN(II)/AG(I) COMPLEXES WITH SALEN SCHIFF BASE EXPRESS PROMISING CYTOTOXIC ACTIVITY IN HUMAN CANCER CELLS
Objective: The aim of our study was to evaluate the influence of two complexes of Zn(II)/Au(I) and Zn(II)/Ag(I) with Schiff base ligand (H2Salen) obtained from the condensation reaction between salicylaldehyde and ethyle...
ERUCA SATIVA LINN.: PHARMACOGNOSTICAL AND PHARMACOLOGICAL PROPERTIES AND PHARMACEUTICAL PREPARATIONS
Eruca sativa (jarjeer) is an annual herb (family Brassicaceae), which contains a wide range of chemicals and minerals with nutraceutical and organoleptic characteristics. Jarjeer was generally used as a food and traditio...