Anticonvulsant effects of medicinal plants with emphasis on mechanisms of action
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2017, Vol 7, Issue 2
Abstract
Epilepsy is a disorder in brain in which clusters of nerve cells, or neurons, occasionally signal abnormally and cause strange emotions, sensations, and behavior, or sometimes muscle spasms, convulsions, and loss of consciousness. Neurotransmitters in central nervous system greatly affect and play a very important part in neuronal excitability. Traditional treatments are still a component of health care system in many communities despite the fact that well-established alternatives are available. In this review article, we addressed epilepsy and its treatments with emphasis on medical plants and introduction of antiepileptic plants and their action mechanisms. Relevant articles published since 2010 were retrieved using the search terms including epileptic seizure, anticonvulsant, medicinal plants, and oxidative stress. Most plants/herbal preparations that are ethnomedically used to treat epilepsy or those which have been tested for anticonvulsant activity were reported. Overall, the results of the published articles show that the symptoms of epilepsy seizure can be inhibited or treated by active ingredients derived from medicinal plants.
Authors and Affiliations
Zahra Rabiei
Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill.
Objective: To determine inhibitory activity of methanolic leaf extract of Piper umbellatum and Persea americana (P. americana) (traditionally used in Cameroon against diabetes) on 毩-glucosidase, 毬-glucosidase, maltase-...
Inhibition of Mahkota Dewa (Phaleria macrocarpa) bioactive fraction on proliferation of human retinoblastoma tumor cells Y-79 through suppression of mRNA level of cyclin E
Objective: To prove the molecular mechanisms of Mahkota Dewa (Phaleria macrocarpa) in suppressing proliferation of human retinoblastoma cells through suppression of cell cycle's gene-regulators expression. Methods: In th...
Anti–oxidative role of quercetin derived from Allium cepa on aldehyde oxidase (OX–LDL) and hepatocytes apoptosis in streptozotocin–induced diabetic rat
Objective To study the role of Quercetin in streptozotocin-induced diabetes in rats. Methods Wistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group received 15 mg/kg (IP...
Science behind cisplatin-induced nephrotoxicity in humans: A clinical study
Objective To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity. Methods We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolyt...
Evaluation of berries of Phytolacca dodecandra for growth inhibition of Histoplasma capsulatum var. farciminosum and treatment of cases of epizootic lymphangitis in Ethiopia
Objective To evaluate the berries of Phytolacca dodecandra (P. dodecandra) for its effect on Histoplasma capsulatum var. farciminosum (HCF) and for the treatment of cases of epizootic lymphangitis (EL). Methods Sample...