Antidepressant activity of Ciprofloxacin and Levofloxacin by forced swim test in Swiss albino mice on chronic administration
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2018, Vol 3, Issue 1
Abstract
Introduction Depression is a neuropsychological disorder with its own course of illness which affects day to day life Fluroquinolones has been shown some antidepressant like effect in our previous acute studyObjectives Antidepressant activity of Ciprofloxacin and Levofloxacin in Swiss albino mice on chronic administration Materials and Methods Swiss albino mice were randomly divided in to six groups of which each weighing 2025 gm and the groups are as follows Group I 1 Gum acacia 10mlkg served as control Group II Imipramine 10mgkg served as reference standarsd Group III and IV Ciprofloxacin 25 amp 50 mgkg respectively Group V amp VI Levofloxacin 25 amp 50 mg respectively Each mouse was administered with respective vehicle drug one every day for 09 days and one hour prior to experiment on 10th day Each mouse was allowed to swim in a jar containing water making sure that its legs does not touch the bottom of the jar and it can swim by keeping its head just above the water surface First two minute reading was not recorded but last four minutes activity was noted for mobility and immobility Increase in the duration of mobility time and lesser the immobility time was considered that test drug is having antidepressant effectResults and Discussion Mean duration of immobility in Forced swim test in control group was 19583 plusmn 231 sec Imipramine standard is 1475 plusmn 187 sec for group III amp IV pretreated with Ciprofloxacin 25mgkg is 146 plusmn 357 sec and 50mgkg is 1755 plusmn 339 sec respectively while group V amp VI pretreated with Levofloxacin 25mgkg amp 50 mgkg is 167 plusmn 260 and 18516 plusmn 306 sec respectively The p value for the both the test drugs in all the doses was lt001 thus showing its significant comparable to Imipramine the standardConclusion Both Ciprofloxacin and Levofloxacin have shown significant antidepressant activity at the dose of 25 and 50 mgkg respectively by forced swim test in Swiss albino mice on chronic administerationKeywords Antidepressant effect Ciprofloxacin Forced swim test Levofloxacin Chronic administration
Authors and Affiliations
Bharath Kumar D, Manohar V. R
Keywords
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- EP ID EP481703
- DOI 10.18231/2456-9542.2018.0004
- Views 95
- Downloads 0
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