Antidepressant activity of “Cissampelos pareria” extract in mice
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2016, Vol 4, Issue 3
Abstract
Depression is a wide spread psychiatric disorder affecting around 5% of the population and it is difficult to predict the patient response to any given treatment. The present study aimed at studying the pharmacological activity of Cissampelos pareria leaves that contain bis benzylisoquinoline alkaloids (BIA), tetrandin, bebriberin, and flavons that are known for their anti anxiolytic activity. These alkaloids act by inhibiting mono amino oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters. The present study was under taken to evaluate the anti depressant activity of “cissampelos pareria” extract in mice at doses of 100 and 200 mg/kg p.o., against standard Imiparamine (10mg/kg) and control (1% gum acacia). Tail suspension test and forced swim test was conducted and duration of immobility was recorded, in both of these tests carried, Cissampelos Pareria (200mg/kg p.o.) produced significant antidepressant activity compared with the standard Imipramine, which was evident from the decreased immobility when extract was used.
Authors and Affiliations
P. Venkata Ravikanth,
Keywords
Related Articles
- EP ID EP569119
- DOI -
- Views 65
- Downloads 0
Development and validation of stability indicating HPLC assay method for Clofazimine capsules
All the Methods which are available are on UV- visible spectroscopy, but there is interference observed at Clofazimine maxima of Clofazimine Related compound-B. Therefore need to develop method on HPLC. Method: To develo...
Ethno-medical and Pharmacological role of PhyllanthusNiruri: A Review
Medicinal plants have been considered as a vital therapeutic aid for the treatment of various ailments of humankind like jaundice, ulcers, skin diseases; diabetes, chest pain and urinary complications etc. There are nume...
Obesity management therapies
Obesity is prominently referred as a lifestyle disease that exhibits itself as one of the major health threat of this day. 65% of the world's population lives in developed countries where overweight and obesity kills mor...
Profile picture of risk factors for breast cancer among community women of Udupi, Karnataka
Globally, breast cancer is considered to be one amongst the most commonly cancer. In India, it is considered to be the second cancer disease among women with most of the affected population is in the urban areas. Accordi...
Development and evaluation of some novel polyherbal anti-inflammatory and analgesic formulations of some Indian spices
Inflammation is linked with a broad range of infectious and non-infectious diseases; hence, also considered on root of the all diseases. The crucial role of inflammatory processes makes possible evaluation research focus...