Antidepressant Activity Of DPP-4 Inhibitors In Albino Mice, An Experimental Study
Journal Title: National Journal of Medical and Dental Research - Year 2018, Vol 6, Issue 4
Abstract
Objective: To evaluate the antidepressant activity of DPP-4 INHIBITOR in mice. Methods: Sixty adult Swiss albino mice weighing 25-30 grams were selected. Thirty were allocated to forced swim test and thirty to tail suspension test models. In each model there were 6 groups. The control group received vehicle (10 ml/kg, p.o) as standard, Imipramine (10mg/kg p.o) and the other groups received sitagliptin linaglitin, saxagliptin, vildagliptin respectively 1 hour prior to the acute study. In chronic study, the drugs were given orally once a day for 10 days and the last dose was given 1 hour before the experiment. Duration of immobility was noted in forced swim test and tail suspension test. Statistical analysis was performed using Mean +/- SEM. ANOVA followed by Dunnett’s test. P< 0.05 was considered statically significant Results:DPP-4 inhibitors produced significant antidepressant effect at all the doses, as indicated by reduction in the duration of immobility compared to the standard. The antidepressant effect was higher with sitagliptin and linagliptin when compared to saxagliptin ,vildagliptin and control. Conclusion: DPP-4 inihibitors sitagliptin and lingaliptin has shown significant antidepressant activity greater than imipramine in mice.
Authors and Affiliations
Saritha MK, Chandrashekar K
Keywords
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Antidepressant Activity Of DPP-4 Inhibitors In Albino Mice, An Experimental Study
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