Antidepressant activity of ethanolic extract of neptunia natans on swiss albino mice
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 3
Abstract
The aim of the study is to study the phytochemical screening and antidepressant activity of ethanolic extract of the neptunia natans leaf extract in Swiss albino mice. The Phytochemicals was extracted using ethanol as a solvent, The maximum tolerated doses study was performed with the dose of 2000mg/ kg of EENN leaf extract and 50 and 100 mg/kg body weight of EENN was selected as test-I and test-II Respectively and imipramine was used as standard drug performed by despair swim test, tail suspension test and locomotor activity on Swiss albino mice. The EENN showed the significant ((p<0.001) antidepressant effect at the dose of 100 mg/kg body weight against control treated group. It is concluded that that the oral administration ethanol extracts of neptunia natans leaf extract shown a significant antidepressant effect at 100mg/kg body weight may be attributed due to the presence phytochemicals such as phenols, flavonoids, tannins, triterpenoids, alkaloids. Hence, further study is needed to identify, isolate the specific phytochemical drug candidate showing antidepressant activity and therapeutic confirmation of EENN leaf extract on different animal models.
Authors and Affiliations
P. Seetharam
Keywords
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