Antidiabetic Activities of Foeniculum Vulgare Mill. Essential Oil in Streptozotocin-Induced Diabetic Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 2
Abstract
Background: Foeniculum vulgare Mill (F. Apiaceae) is an ancient common herb and spice known to the ancient Egyptians and Greeks, traditionally used as a carminative, a weak diuretic and lactation stimulant. Aim: To evaluate the essential oil of Foeniculum vulgare Mill for its hypoglycaemic effect and antioxidant activity in addition to histopathological study in streptozotocin induced diabetic rats. Material and Methods: Rats were divided into 3 groups; normal control, diabetic control, and diabetic group receiving orally Foeniculum vulgare Mill essential oil (30 mg/kg bw).The dose of essential oil was chosen according to its LD50. Serum glucose and whole blood glutathione peroxidase were measured in addition to histopathological study of rats kidney and pancreas. Results: Ingestion of essential oil ofFoeniculum vulgare Mill to diabetic rats corrected the hyperglycemia from (162.5 ± 3.19 mg/dl) to (81.97 ± 1.97 mg/dl) with p<0.05 and the activity of serum glutathione peroxidase from (59.72 ± 2.78 U/g Hb) to (99.60 ± 6.38 U/g Hb) with p<0.05. Also, improved the pathological changes noticed in their kidney and pancreas. Conclusion: Essential oil of Foeniculum vulgare Mill corrected the hyperglycemia and pathological abnormalities in diabetic induced rats, which could be in part through its antioxidative effect and restoring of redox homeostasis. This makes the possibility of its inclusion in antidiabetic drug industry.
Authors and Affiliations
Neveen Abou El-Soud| National Research Center, Complementary Medicine, Cairo, Giza 12311, Egypt, Nabila El-Laithy| National Research Center, Medical Biochemistry, Cairo, Giza 12311, Egypt, Gamila El-Saeed| National Research Center, Medical Biochemistry, Cairo, Giza 12311, Egypt, Mohamed Salah Wahby| National Research Center, Cultivation and Production of Aromatic and Medicinal Plants, Cairo, Giza 12311, Egypt, Mona Khalil| Gizan University, Medical Applied Science, Medical Chemistry, Gizan, Saudi Arabia, Fatma Morsy| National Research Center, Histology and Pathology, Cairo, Giza 12311, Egypt, Nermeen Shaffie| National Research Center, Histology and Pathology, Cairo, Giza 12311, Egypt
Keywords
Related Articles
- EP ID EP8796
- DOI 10.3889/MJMS.1857-5773.2011.0173
- Views 344
- Downloads 14
Slobodan Nikolik. SPORT MEDICINE. Skopje: Nikolik; 2009. 600 pages; ISBN 978-9989-2594-9-4, Price MKD 1500,00
Field of medicine: Sport medicine Audience: Sports medicine specialists, general practitioners, students in medicine Purpose: This is a review of the book SPORT MEDICINE by d-r Slobodan Nikolik, and represents the au...
Heroin Maintenance Treatment - Are the Further Investigation Needed?
The aim of this review is to give new emphasis to key aspects of the proposed treatment of drug addiction. Surveys for so called “second-line†treatment of drug addiction, with heroin (diacetylmorphine) as a pharma...
Some Anatomic-Topographic Features of Common and Right Hepatic Ducts and their Constituents
Aim. Anatomic-topographic features of the common duct and ducts of the right functional liver are attributes of the diagnostic-surgical and transplantation liver practice. In connection with this notion, this study has...
The Impact of Social Assistance Programs on Reducing Inequities in Health Care Among Vulnerable Groups in the Republic of Macedonia (A Small Scale Descriptive Study)
Aim. The aim of this research was to look at the impact of social assistance programs on reducing social inequities in health care among the vulnerable groups in Macedonia. Materials and methods. A small scale descrip...
Macedonian Medical Journals Have Very Limited Scientific Influence
Aim. The aim of this report was to evaluate the Macedonian medical journals for their scientific influence according to the internationally recognized citation metrics indexes. Material and methods. Macedonian medical...