Antidiabetic Activity of Thalassia Hemprichii (Seagrass) In Alloxan Induced Diabetic Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Objectives: To study the antidiabetic activity of Thalassiahemprichiiin normal and alloxan-induced diabetic mice. Materials and Methods: Ethanolic extract of fruiting bodies of Thalassiahemprichiiwas tested for their antidiabetic activity. BALB/C mice (25-30gm) were divided into four groups of six animals each normal control mice, diabetic control mice, diabetic mice post-treated with standard drug glibenclamide and diabetic mice treated with Thalassiahemprichiiethanolic extract. Blood glucose level, biochemical parameters such as serum total cholesterol (TC), LDL, HDLVLDL,triglyceride creatinine, urea, and Serum glutamate oxaloacetate transaminase (SGOT) and Serum glutamate pyruvate transaminase (SGPT) were studied in alloxan induced diabetic mice after 15 days of treatment. Results: Animals treated with the ethanolic extract of Thalassiahemprichii showed a significant decrease in serum glucose level (P<0.01) .The post-treatment with Thalassiahemprichiiextract reduced serum cholesterol, triglyceride and LDL-cholesterol.The serum HDL cholesterol was significantly increased in post-treated groups. The serum creatinine, urea levels were significantly reduced in post-treated group, whereas the decrease in the body weight was arrested by administration of Thalassiahemprichiiextract to the animals. Discussion and Conclusion: The consumption of Thalassiahemprichiiproduced a significant hypoglycemic effect in diabetic mice and it is capable of improving hyperlipidemia and the impaired kidney functions in alloxan-induced diabetic mice. Thus, indicating that the ethanolic extract ofThalassiahemprichii could be added in the list of medicinal preparations beneficial in diabetes mellitus.
Authors and Affiliations
Bindhu Jayaprakash, Sivapriya Veeraiyan,, Silambarasan Gunaseelan, Yasodha Purushothaman, Girija Raja
Keywords
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