Antidiabetic and antioxidant potential of Curcuma mangga Val extract and fractions
Journal Title: Asian Journal of Agriculture and Biology - Year 2018, Vol 6, Issue 2
Abstract
Diabetes is a chronic metabolic disorder and characterized by high blood glucose level that defects in secretion of insulin. Oxidative stress and excess of free radicals have been documented in diabetes occurrence. Curcuma mangga Val. is one of traditional medicine that has potency for diabetic treatment. The present study was conducted to evaluate the antidiabetic and antioxidant effects of Curcuma mangga Val extract (CME) and fractions. In this study, the antioxidant activity of four fractions of CME (water, hexane, ethyl acetate, and butanol fraction) were measured using nitrite oxide (NO) and H2O2-scavenging activity assay, while antidiabetic activity of those fractions were measured by α-glucosidase activity assay. These fractions were also compared to antidiabetic drug, namely acarbose. In the NO-scavenging activity, the butylated hydroxytoluene (BHT) had the highest activity (IC50 69.75 µg/mL) compared to all fractions of CME and acarbose (ACR). Ethyl acetate fraction of C. mangga extract (EACM) showed the highest in H2O2-scavenging activity (IC50 162.78 µg/mL) compared to marker compound (BHT) (IC50 179.86 µg/mL) and other fractions. Hexane fraction of C. mangga (HCM) showed the highest α-glucosidase inhibitory activity (IC50 182.45 µg/mL). To conclude, the fractions of C. mangga extract could be used as an alternative in the development of antioxidant and antidiabetic medicine.
Authors and Affiliations
Dwiyati Pujimulyani
Keywords
Related Articles
- EP ID EP603393
- DOI -
- Views 75
- Downloads 0
Splitting of nitrogen application through growth stages in various sunflower cultivars to improve their vegetative growth and seed yield
A field experiment was carried out in spring seasons of 2012 and 2013 to increase the efficiency of nitrogen application in spite of that no splitting nitrogen has practiced for the studied cultivars. Five splitting trea...
An updated checklist of Sepsidae (Diptera) from Gilgit-Baltistan, Pakistan
An updated checklist of twelve species of black scavenger flies under four genera has been enlisted from Gilgit-Baltistan. Two species belonging to subfamily Sepsinae are recorded for the first time from Baltistan divisi...
Comparative analysis of some winter crops area estimation using landsat-8 and sentinal-2 satellite imagery
Estimating crop area is a key factor for any crop monitoring and agricultural management system. Having annual information on crop acreage and production change is sufficient for agricultural decision makers and planners...
Isolation and identification of phytoplankton from aquatic ecosystems of Lampung Mangroves Center (LMC) as biological feed
In this paper we studied the isolation and identification of phytoplankton from aquatic ecosystems of Lampung Mangroves Center (LMC) as biology feed. The analysis of sea water quality parameters in the location of the st...
Isolation, identification and characterization of dye degrading bacteria from dyeing industry effluent and degradation process optimization against Novacron Red SB
Water pollution due to the desertion of enormous volume of effluent like synthetic dyes mostly azo dyes from the textile dyeing industries has become an alarming trend in the present world. Biological degradation of syn...