Antidiarrheal and Antimicrobial Activities of Ethno Medicinal Plant: Mikania scandens (L) Willd
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 3
Abstract
Abstract: The aim of the present study was carried out to investigate the antidiarrheal and antimicrobial potential of both ethanol and aqueous extracts of aerial parts of Mikania scandens .In vivo Antidiarrheal activity of M.scandens ethanol and aqueous aerial extracts at a dose of 100 mg/kg and 200 mg/kg BW were studied using experimentally induced castor oil diarrheal in Wister rats of both sexes and compared to standard drug loperamide (3mg/kg p.o). During this study different parameters like time of onset of diarrhoea, total nos. of faecal output (frequency of defecation) and weight of wet faeces, nos. of wet faeces were assessed. In vitro Antimicrobial activity (zone of inhibition, minimum inhibitory concentration, minimum bactericidal concentration, minimum fungal concentration) were performed by using four bacterial strains.( gram positive, & gram negative) and two fungal strains. Data were analysed using one way ANOVA. (Analysis of Variance).The results of antidiarrheal studies showed that over four hours, both the extracts significantly protected (p<0.05) the rats against castor oil induce diarrhoea, inhibited gastrointestinal transit, reduced the frequency of defecation in the treated groups compared with the untreated group. The crude ethanol extracts also showed good antimicrobial activity against all tested organisms. The obtained results allow justifying the traditional uses of Mikania scandens possess good antidiarrheal and antimicrobial activities .Results of the present study has revealed credence to the traditional usage of this plant as antidiarrheal and antimicrobial agent.
Authors and Affiliations
Jana Soma, Yalagatti S Manjunath, Gupta V Rama Mohan
Keywords
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