ANTIFERTILITY EFFECT OF ALCOHOLIC STALK EXTRACT OF PIPER BETEL LINN ON FEMALE ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 1
Abstract
To study the antifertility effect of methanolic extract of Piper betel Linn (PBL) in female albino rats. Three months young female albino rats were administered with graded doses of methanolic extract of Piper betel Linn for 30 consecutive days and the effect of the extract on the estrus cycle was assessed by observing the changes produced in the vaginal smear, over the 30 days observation period, in comparison to the control. The rats treated with PBL showed highly significant (p<0.05), dose-dependent decrease in the numbers of estrus phase, in comparison to control rats. Large, cornified cells appeared after proestrus phase and number of cornified cells per field decreased. There was no significant change in the number of proestrus, Metestrus or diestrus phases of the estrus cycle, in the PBL treated group in comparison to control. Anestrus phase appeared in all the rats treated with PBL extract, which was not observed in the control group. The methanolic extract of Piper betel Linn possesses antifertility activity in female albino rats.
Authors and Affiliations
Manas Pradhan , Manjushree Mohanty , Sabita Mohapatra, Samira Sahoo
Keywords
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