Antifungal Activity and Phytochemical Analysis of Aqueous Extracts of Ricinus communis and Punica granatum
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 1
Abstract
In the present investigation, the aqueous leaf and pericarp extracts of castor oil plant (Ricinus communis) and pomegranate (Punica granatum) were evaluated for antifungal activity against Candida species and subsequently phytochemical analysis of the crude extracts was carried out to determine the active phytochemical constituents responsible for antifungal activity. It was observed that aqueous leaf extract of R. communis was effective in inhibiting Candida albicans, C. glabrata and C. tropicalis with zone of inhibition ranging between 17mm and 32 mm followed by aqueous pericarp extract of Punica granatum which inhibited two species of Candida namely C. glabrata and C. albicans with zone of growth inhibition between 24mm and 37mm. All the Candida species, except C. tropicalis were resistant to the positive control, ketoconazole. Phytochemical screening of crude leaf and pericarp aqueous extracts of both the plants revealed the presence of tannins, steroids and flavonoids. The results indicate that the aqeueous leaf and pericarp extracts of Ricinus communis and Punica granatum might be exploited as natural drug for the treatment of several infectious diseases caused by these organisms
Authors and Affiliations
Pranay Jain1* and Gulhina Nafis2
Keywords
Related Articles
- EP ID EP85747
- DOI -
- Views 127
- Downloads 0
Microwave Assisted Organic Synthesis: An Overview
Microwave heating refers the use of electromagnetic waves ranges from 0.01 m to 1 m wavelength of frequency 30 GHz to 0.3 GHz to generate heat in the material. These microwaves lie in the region of the electromagnetic sp...
Determination of Calcipotriene and forced its degradation behavior by HPLC
A simple, specific, sensitive, precise stability-indicating high-performance liquid chromatography method for determination of Calcipotriene was developed and validated. A Zorbax 300 SBC 18 column (250*4.6 mm, 3.5 μ) in...
Isolation and purification of antibacterial protein from Euphatorium odoratum: A seasonal folk medicinal plant
A potent protein with molecular weight of 15.85 kDa exhibited significant antibacterial activity was isolated and purified from leaf extract of Euphatorium odoratum. It is a seasonal girijan folk medicinal plant, of Co...
A subchronic oral toxicity study in rats of ursodeoxycholic acid tablets prepared with micronized drug
Title: A Subchronic Oral Toxicity Study in rats of Ursodeoxycholic Acid Tablets Prepared with Micronized Drug. Aim: The purpose of this study was to find out the potential toxicity of micronized ursodeoxycholic acid in t...
An overview on silviculture and traditional therapeutic uses of Gmnelina arborea Roxb.
The number of patients seeking alternate and herbal therapy is growing exponentially. Herbal medicines are the synthesis of therapeutic experiences of generations of practicing physicians of indigenous systems of medicin...