Antifungal Activity of Iris ensata against Trichosporon asahii Causing Invasive Trichosporonosis
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 1
Abstract
Trichosporon sp. are widely distributed in nature and can predominantly be found in the environmental substrates, such as soil, birds, vegetables, water, and decomposing wood. These fungi can colonize skin and, less frequently, respiratory and gastrointestinal tracts of humans. Currently, the genus Trichosporon sp. is considered one of the most important emerging causes of invasive infection in immune compromised patients, with T. asahii being the most frequently reported species. In this study, T. asahii was procured from MTCC and its sensitivity was checked against different solvents (Methanol, Ethanol, Acetone, and Chloroform) of Iris ensata, a medicinal plant. Zone of inhibition and MIC were evaluated using Agar well diffusion assay and Tube dilution broth assay. Ketoconazole and Nystatin B were used as positive controls. Phytochemical screening was done to determine the phytochemicals present in the plant. The methanol extract was found to be most effective compared to other solvent extracts and positive controls. Phytochemicals play a major role in this anti Trichosporon activity.
Authors and Affiliations
Veena Uniyal, R. P. Bhatt, Seema Saxena
Keywords
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- EP ID EP670635
- DOI 10.21276/ijlssr.2018.4.2.4
- Views 98
- Downloads 0
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