Antihyperlipidemic and Antibacterial Activities of Baccaurea Courtallensis Leaves
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 3
Abstract
The present study evaluated the antihyperlipidemic and antibacterial activities of B. courtallensis extract. The antihyperlipidemic effect of B. courtallensis methanol extract was studied in Triton WR-1339 and high fat diet–induced hyperlipidemic rats. In Triton WR-1339 and high fat diet-induced hyperlipidemic rats, B. courtallensis (200 and 400 mg/kg) exerted a significant (P ≤ 0.05, P ≤ 0.01, P ≤ 0.001) alteration in serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) to near normal. The antibacterial activity of B. courtallensis was evaluated by agar-well diffusion method against selected gram negative bacteria: Bacillus subtilis, Pseudomonas aeruginosa and gram positive bacteria: Staphylococcus aureus, Escherichia coli. B. Courtallensis extract exhibited pronounced activity against all the bacterial strains tested and the activity was comparable to the standard drug Amoxicillin (100 µg/ml). The results of the present study demonstrate that the methanolic extract of B. courtallensis possess antihyperlipidemic and antibacterial activities.
Authors and Affiliations
Sreelakshmi AG, Thomas N, Carla B and Sunil C*
Keywords
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- EP ID EP745765
- DOI 10.23880/oajpr-16000116
- Views 26
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