ANTIMICROBIAL POTENT OXAZINE-2-AMINE DERIVATIVES
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 5
Abstract
Objective: To synthesize thirteen effective microbial potent oxazine-2-amine derivatives and evaluate the antimicrobial activities of these compounds. Material and methods: The solvent-free solid fly-ash: H2SO4 catalyzed cyclization of 4-bromo-1-naphthyl chalcones and urea under microwave irradiation technique was utilized for the synthesis of oxazine derivatives. The synthesized oxazines were characterized by their physical constants and spectroscopic data. The Bauer-Kirby disc-diffusion method of measurement of zone of inhibition was used for evaluation antimicrobial activity of synthesized oxazines. Results: The cyclization was effective and this reaction gave more than 80% yield. The catalyst was reused up to five times consecutively without appreciable decreasing of yield. All compounds were active against their microbial strains. Conclusions: This solvent-free synthetic method was effective for the synthesis of oxazine derivatives. The amino, dimethylamino, halogens, methoxy and methyl substituted oxazines shows significant antibacterial activity. Chloro, hydroxy and nitro substituted oxazine derivative have shown significant antifungal activity.
Authors and Affiliations
Ganesamoorthy Thirunarayanan
Keywords
Related Articles
- EP ID EP439087
- DOI -
- Views 137
- Downloads 0
IMPACT OF SELF- HELP MANUAL ON PROMOTION OF RESILIENCE IN DEPRESSIVE PATIENTS ADMITTED IN GOVERNMENT HEAD QUARTERS HOSPITAL AT ERODE, INDIA -A WAIT-LIST CONTROL GROUP
Context: It is incorporated readily that self-help manual is an adjunct work of mental health nurse and other professionals in promoting resilience and enhancing recovery in people with moderate depression in the communi...
ETHNO MEDICINAL PLANTS IN FRINGE FOREST OF BALPHAKRAM NATIONAL PARK, MEGHALAYA
Objective: The aims of present study were to document wild medicinal plants found in fringe forest of BNP and to explore potential species for phyto-chemical and pharmacological studies. Methods: Fieldwork was conducted...
ANALYSIS OF INFLUENTIAL FACTORS ON NUTRITION BEHAVIORS OF STUDENTS IN SALAMAT HIGHER EDUCATION COMPLEX OF CHABAHAR
Background and aim: Diet and nutrition play a very important role in human life and health from birth to death. The present study aims at determining influential factors on nutrition behaviors of the students of Salamat...
TREATMENT OUTCOMES OF TUBERCULOSIS AT TB/DOTS UNIT OF TERTIARY CARE CENTRE
Background: Countrywide revised national tuberculosis control programmes, is among mega ventures, needing feedback on practical success at the peripheral level. Objective: Treatment outcome profile at medical college bas...
HARPIC POISONING: A REPORT ON ACUTE AND DELAY MANIFESTATIONS OF TWO CASES
Aim: Harpic poisioning is a life threatening condition were it requires proper assessment for long term manifestations.Objective:The main Objective of the study ia to explain acute and chronic manifestations in harpic po...