Antimicrobial resistance pattern in ventilator-associated pneumonia in an intensive care unit of Babol, northern Iran
Journal Title: Journal of Acute Disease - Year 2018, Vol 7, Issue 2
Abstract
Objective: To investigate antibiotic resistance pattern of ventilator-associated pneumonia (VAP) generating microorganisms, and quantitative culture and determining antibiotic sensitivity. Methods: This cross sectional study was performed on 50 patients suffering from VAP in intensive care unit of Ayatollah Rouhani Hospital, Babol, Iran during 2014–2015. VAP was probable for them based on clinical signs and the criteria of Clinical Pulmonary Infection Score standards. Lower respiratory samples were given under bronchoalveolar lavage and quantitative culture was done on them. Afterwards by microdilution method, minimal inhibitory concentration based on respective microorganisms, considering clinical pulmonary infection score were determined. Results: From 50 investigated samples in this study, the most common microorganisms were Acinetobacter baumannii (A. baumannii) (70%) then Pseudomonas aeruginosa (12%), Staphylococcus aureus (8%) and Klebsiella pneumonia (3%). In our study A. baumannii showed approximate 100% resistance to all antibiotics, in a way that A. baumannii resistance to imipenem and meropenem and piperacillin/tazobactam each was 97.1%. The most resistance of Pseudomonas aeruginosa was 66.7% to each cefepime and ceftazidime and clavulanate/ticarcillin. Staphylococcus aureus showed 75% resistance to nafcillin, cloxacillin and resistance in case of vancomycin was not seen. Conclusion: In current study, A. baumannii had the most prevalence among VAP and this species is resistant to most of antibiotics. Using ceftazidime, cefepime and clavulanate/ticarcillin, in treatment of the patients suffering VAP is not reasonable.
Authors and Affiliations
Mahmoud Sadeghi-Haddad-Zavareh, Hadi Ahmadi Jouybari, Mostafa Javanian, Mehran Shokri, Masomeh Bayani, Mohammad Reza Hasanjani Roushan, Arefeh Babazadeh, Soheil Ebrahimpour, Parviz Amri Maleh
Keywords
Related Articles
- EP ID EP407357
- DOI 10.4103/2221-6189.233015
- Views 108
- Downloads 0
Unusual isolated extrapulmonary sarcoidosis: Case report
Sarcoidosis is a granulomatous condition with unidentified etiology. This disease should be considered in differential diagnosis if non-caseating granulomas is noted in biopsies, because numerous cases presented with no...
Dorsal midbrain syndrome secondary to pineal gland tumours: case series and review on manifestations, management and outcome
Dorsal midbrain syndrome or Parinaud syndrome is a supranuclear brainstem syndrome involving the vertical gaze centre. These are case series with three patients who were diagnosed with dorsal midbrain syndrome secondary...
Research progress of transfering mitochondria application in nanotubes in treatment of acute lung injury sepsis
Acute lung injury (ALI) is a common complication of sepsis with characteristics of acute onset, rapid change in the disease and high mortality. Since current clinical treatment can only alleviate the unfavorable conditio...
Traumatic transection of main stem bronchus with unexpected clinical presentation- A case report
Tracheobronchial injury is very challenging in diagnosis and treatment. Highly suspicious airway injury and early diagnosis is recommended. We present a case of 39 years-old woman suffering from acute respiratory failure...
Emergency treatment of proximal femural fracture within 48h: The Umbria Region experience
Objective: To study the main aspects of osteoporotic emergency fracture of the hip in the Umbria Region in the years 2006-2011. Methods: The study was conducted from January 1 of 2006 to December 31 of 2011, and included...