Antimycobacterial and antimicrobial studies of newly synthesized 3-(4-(6- methylbenzo[d]thiazol-2-yl) phenyl)quinazolin-4(3H)-ones
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 1
Abstract
7-Chloro-2-(substituted)-3-(4-(6-methylbenzo[d]thiazol-2-yl) phenyl) quinazolin-4(3H)-ones 1- 12 have been prepared from the substituted acids 1(a-l), which were converted to substituted acetyl chlorides 2(a-l) and cyclized with 4-chloro anthranilic acid afforded substituted benzoxazines 4(3H)-ones 3(a-l). Further reaction with 4-(6-methylbenzo[d]thiazol-2-yl)aniline A gives desired compounds 1-12. The title compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium (conventional method) and antimicrobial activity against various bacteria and fungi using broth microdilution method. Compounds 3b, 3i, 3h, 3e, 3j, 3k, 3l, 1, 2, 4, 8, 9, 10, were emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compounds 3k, 1, 4 and 10 showed better antitubercular activities compared to rifampicin and isoniazid.
Authors and Affiliations
Asif R. Shaikh, Navin B. Patel, Dhanji Rajani
Keywords
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