ANTINOCICEPTIVE ACTIVITY OF SRI LANKAN BLACK TEA BREW (CAMELLIA SINENSIS L.) IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
The aim of this study was to investigate the antinociceptive potential of warm black tea brew of Camellia sinensis (L.) O. Kuntze (Theaceae). This was tested in rats using high grown Sri Lankan Dust grade No: 1 black tea and four models of noceiception (tail flick, hot plate, writhing and formalin tests). Four doses of black tea brew (BTB) 84, 167, 501, 1336 mg/ml was made and orally administed to rats (N = 9/group) for testing purposes. The results showed that strong BTB possesses marked and significant (P < 0.05) antinociceptive activity having a rapid onset and a short duration of action. Further, the BTB also had profound and significant (P < 0.05) antihyperalgesic activity (in terms of carrageenan induced thermal hyperalgesic test and formalin test), in vitro antioxidant activity (DPPH method) and antihistamine activity (in terms of wheal test). The BTB-induced antinociception was blocked by nalaxone but not by atropine or metachlopramide indicating opioid receptor mediation. Further, even with subchronic administration of BTB, tolerance was not developed. It is concluded that BTB of C. sinensis has mild to moderate oral antinociceptive activity with swift onset and short duration of action which is mediated via opioid, antioxidant and antihistamine mechanisms.
Authors and Affiliations
Wanigasekara Ratnasooriya , Saminda Fernando
Keywords
Related Articles
- EP ID EP108530
- DOI -
- Views 102
- Downloads 0
ANTITUMOR ACTIVITY OF METHANOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES AGAINST EHRLICH ASCITES INDUCED CARCINOMA IN MICE
Terminalia catappa belongs to the family combretaceae and is popularly known as badam.It is a well known herb in Ayurvedic system of medicine The aim of the present study is to evaluate the effect of methanolic extract...
MICRONEEDLE AS A NOVEL DRUG DELIVERY SYSTEM: A REVIEW
Patch-based transdermal drug delivery offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections relating to issues such as patient acceptability and injection safety. However, co...
VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CEFADROXIL IN TABLET DOSAGE FORM
A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of cefadroxil in tablets. The method is based on the reaction of cefadroxil with ninh...
A DISCUSSION ON INDIAN INDIGENOUS LAL: ORLYSATE
To discuss the use of LAL by using a reagent called ORLYSATE (LAL) –made from the (blue blood) hemolymph of the Orissan Horse Shoe Crab. Process technology for ORLYSATE has been developed in India {by this author}....
ASSESSMENT OF THE ACCEPTABILITY OF CONTRACEPTIVE USE AMONG THE WOMEN OF RURAL AND URBAN AREAS OF RAWALPINDI, PAKISTAN
Aim of the study was to document the prevalence of use of Contraceptives among the rural and urban areas of Rawalpindi, Pakistan. Specific objectives were to identify the percentage of women using contraceptive, to docum...