Antinociceptive Activity of the Crude Methanolic Extract of Pseudocedrela kotschyi and Its Chloroform and n-butanol Fractions in Mice
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2011, Vol 6, Issue 3
Abstract
Pseudocedrela kotschyi has been extensively used in traditional medicine for the treatment of rheumatism, malaria, dysentery and epilepsy. The antinociceptive effects of the crude methanolic extract, n-butanol and chloroform fractions of P. kotschyi were investigated in different experimental models in mice: (1) hot plate, (2) tail flick, (3) acetic acid induced writhing and (4) formalin induced test. In the writhing test 200 mg/kg of the crude extract significantly (P < 0.05) reduced the number of writhes and produced an 88.1% inhibition. The chloroform and n-butanol fractions produced 98.59 and 92.62% inhibition of writhes respectively. In the formalin induced test 100 and 200 mg/kg of the crude methanolic extract significantly (P < 0.01) produced late phase analgesia. Similarly, 200 mg/kg of the chloroform fraction significantly (P < 0.01) reduced paw licking behaviour in mice in both early and late phases of the experiment. However, at the doses tested, no significant activity was found in the hot plate and the tail flick test. The results suggest that P. kotschyi methanol extract at 200 mg/kg dose is effective in non-steroidal anti-inflammatory drug type anti-nociception activities.
Authors and Affiliations
Kabiru Abubakar
Keywords
Related Articles
- EP ID EP183830
- DOI -
- Views 96
- Downloads 0
Influence of Ortho Group Introduction on the Alkylation of Phenolic Hydroxyl of Apocynin
Apocynin was widely studied in inflammation and oxidative stress related diseases and showed effectiveness. Structure-activity relationship study was carried out and intended to figure out new lead compounds of better ef...
Indicators of Internal Homeostasis in a Clinical Case Foetus in Fetu
Blastopathy is a pathology that occurs during the blastula period, within the first 15 days from the moment of fertilization until embryo- and trophoblast ejection. Etiology of blastopathy is often unclear. This malforma...
A Clinical Study of Secondary Haemorrhoids and Its Management
Background Haemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of haemorrhoids is rectal bleeding associated with bowel movement. The abnor...
Post-Cyclone Poisonings in Paediatric Age Group: An Abnormal Demography
Tropical cyclones cause substantial damage to Odisha, one of the coastal states of India, because of the geographical situation and dense population living in the coastal belts. Poor housing is the major cause of increas...
Comparative Study of Functional Outcome in Colles’ Fracture Treated Conservatively by Closed Reduction and Cast and Closed Reduction, Kirschner Wire and Cast
Displaced Colles’ fractures are generally treated by closed reduction and below elbow cast application. Malunion is a common complication resulting in pain, mid carpal instability and post-traumatic arthritis. Fracture s...