ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF PENTACLETHRA MACROPHYLLA AQUEOUS EXTRACTS IN MICE.
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2006, Vol 3, Issue 1
Abstract
The aqueous leaf, stem – bark, seed and fruit pericarp extracts of Pentaclethra macrophylla were examined for their cytotoxicity, while only the leaves and seeds were tested for analgesic and anti-inflammatory activities using in-vivo and in-vitro experimental models. Cytotoxicity haemagglutination assay revealed the following order of toxicity among the plant parts: fruit pericarp > stem - bark > seed > leaf with 71.4, 25.6, 5.3, and 0.5 haemagglutination titre values respectively. The extracts at 30 and 60 mg/kg exhibited analgesic activity and anti-inflammatory property using the flick and hot plate tests, acetic acid induced writhing test; and leucocyte counts, pulmonary oedema and oedema paw of mice in a dose-dependent manner. These findings therefore explain and justify ethnomedical uses of Pentaclethra macrophylla in the treatment of itching (inflammatory response) and pain in animals and in man.
Authors and Affiliations
Charles Okorie, E. Oparaocha, Clement Adewunmi, E Iwalewa, Simeon Omodara
Keywords
Related Articles
- EP ID EP82304
- DOI -
- Views 128
- Downloads 0
ETHNOMEDICINAL PLANTS USED BY THE VALAIYAN COMMUNITY OF PIRANMALAI HILLS (RESERVED FOREST), TAMILNADU, INDIA. - A PILOT STUDY.
Herbal medicine is widely practiced from ancient period throughout the world. These medicines are safe and environment friendly. According to WHO about 80% of the world’s population relies on traditional medicine...
Traditional medicine development for medical and dental primary health care delivery system in Africa
Traditional African Medicine (TAM) is our socio-economic and socio-cultural heritage, servicing over 80% of the populations in Africa. Although, it has come a long way from the times of our ancestors, not much significan...
IN VIVO ANTIMALARIAL AND CYTOTOXIC PROPERTIES OF ANNONA SENEGALENSIS EXTRACT
The in vivo animal antimalarial and in vitro cytotoxic activities of the methanol extract of Annona senegalensis Pers. (Annonaceae) was investigated in this study. The in vivo antimalarial activity of the methanol extrac...
An investigation on antimicrobial activity of endemic <i>origanum solymicum</i> and origanum bilgeri from Turkey
The methanol extracts obtained from endemic [i]Origanum solymicum[/i] P. H. Davis and [i]Origanum bilgeri[/i] P. H. Davis have been investigated for their antimicrobial activity. Antimicrobial activity was determined Esc...
HYPOGLYCAEMIC AND ANTIDIABETIC EFFECT OF ROOT EXTRACTS OF CEIBA PENTANDRA IN NORMAL AND DIABETIC RATS
The effect of the root bark extract of Ceiba pentandra (Linn) in normal and streptozotocin-induced diabetic rats was studied. Blood glucose levels were determined after oral administration of graded doses of C. pentandra...