Antioxidant activity of Allanblackia floribunda trunk bark ethanol extract on alcohol-induced hypertensive rats
Journal Title: Trends in Phytochemical Research - Year 2019, Vol 3, Issue 2
Abstract
Oxidative stress is involved in many chronic diseases. The ethanol extract of Allanblackia floribunda (A. floribunda) was investigated for the antioxidant and antihypertensive activities on alcohol hypertensive rat’s model. The free radical scavenging and antioxidant activities of plant extracts were evaluated in vitro by DPPH and ABTS assays, the ferric reducing antioxidant power assay and chelating ability on ferrous ions. Alcohol-induced hypertensive rats (AHR) were obtained by oral administration of ethanol (3 g/kg/day during 8 weeks) followed by 4 weeks of concomitant treatment with A. floribunda (100 and 200 mg/kg) and ethanol. Hemodynamic parameters were evaluated using the direct cannulation method. The effects of the extract on lipid profile, kidney and liver functions as well as oxidative stress markers were evaluated using colorimetric method. A. floribunda significantly reduced the mean blood pressure. The plant extract protected against the deterioration in lipid profile, reduced kidney and liver impairment, malondialdehyde (MDA) and increased the reduced glutathione (GSH) concentrations in organs. The total phenolic content of A. floribunda extract was found to be 76772.5 μg equivalent catechin/g. Antioxidant potential of the extract was higher with DPPH assay as compared to ABTS assay. These results suggest that the protective effect of the ethanol extract of A. floribunda in alcohol-induced hypertension was in part due to its antioxidant properties.
Authors and Affiliations
Danielle Claude Bilanda; Alice Louise Woguia; Paul Désiré Djomeni Dzeufiet; Pierre Kamtchouing; Théophile Dimo
Keywords
Related Articles
- EP ID EP680638
- DOI -
- Views 151
- Downloads 0
The rhizome essential oil of Curcuma aeruginosa Roxb. (Zingiberaceae) from Vietnam
The volatile compounds identified from the rhizome oil of Curcuma aeruginosa Roxb (Zingiberaceae) collected from Cham Chu Natural Reserve, Tuyen Quang Province, Vietnam, are reported. The plant sample was air-dried for t...
Chemical constituents, antioxidant and antibacterial activities of the hexane extract of Alchemilla sericata Reichenb
The hexane extract from the aerial parts of Alchemilla sericata Reichenb. which was collected from Khalkhal-Asalem road, Ardabil Province, northwestern Iran, was obtained using a commercially available Soxhlet apparatus....
Molecular simulation of polyketides isolated from the endophyte Phialophora verrucosa
Endophytic fungi are a wealth of new bioactive metabolites with vast applications in drug discovery. The methyl alcohol extract obtained from the culture of the Phialophora verrucosa Medlar., the endophytic fungus of Sen...
Biological activities of the methanolic extracts and compounds from leaves and twigs of Diospyros zenkeri (Gürke) F. White (Ebenaceae)
This study aimed for investigating chemical constituents and biological activities of Diospyros zenkeri (Gürke) F. White. 14 known secondary metabolites have been isolated from the leaves and the twigs of D. zenkeri such...
Phytoconstituents profiling of Cissus rotundifolia (Forssk.) Vahl. by HPLC-MS/MS, and evaluation of its free radical scavenging activity (DPPH) and cytotoxicity
Characterization of phytoconstituents in the 70% methanolic extract of Cissus rotundifolia (Forssk.) Vahl. was performed using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry...