Antioxidant activity of some newer dihydro quinazolin-4-one derivatives
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2015, Vol 5, Issue 5
Abstract
4-chloro anthranilic acid with ethyl chloro formate to get 7-chloro-1H-benzo[d][1,3]oxazine-2,4-dione (4-chloro isaticanhydride). A mixture of 4-chloro isatic anhydride, P-hydroxy aniline undergoes condensation with various aromatic aldehydes to give the products 7-chloro-3 hydroxy phenyl 3- substituted phenyl-2,3-dihydroquinazolin-4(1H)-one. The obtained product further condensed with amine to get the solid product of 3-hydroxy phenyl 3- substituted phenyl -7-amino- 2,3- dihydroquinazolin-4(1H)-one. The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their anti-oxidant activities.
Authors and Affiliations
D. Jothieswari , K. Bhaskar Reddy
Keywords
Related Articles
- EP ID EP144265
- DOI -
- Views 80
- Downloads 0
Isolation and screening of alkalophilic actinobacteria, for biosynthesis and characterization of silver nanoparticles
The present study reports the extracellular biosynthesis of silver nanoparticles by alkalophilic Streptomyces species and its characterization. The biological synthesis would be beneficial because the development of cle...
Protein modelling, identification of de novo chemical inhibitor and QSAR studies on PCOS (Polycystic Ovary Syndrome) using cheminformatics software and tools
In this Insilico research project, Polycystic Ovary syndrome analysis was carried out. Protein modeling and drug designing were major steps for delivering the best drug candidates for disease target. The identified prote...
Design and RP - HPLC Method for the Simultaneous determination of Valsartan and Hydrochlorothiazide in Bulk and in Pharmaceutical Formulation
A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of valsartan and hydrochlorothiazide in bulk and in pharmaceutical formulation using RP - C18 column. The...
Identification of De Novo drug candidate for skin cancer using cheminformatics method
Since 2010, skin cancers result in 80,000 deaths a year, 49,000 of which are due to melanoma and 31,000 of which are due to non-melanoma skin cancers. In this paper, we focus on MCR1 protein which acts as a potential tar...
Toxic effects of acephate in Poecilia sphenops
Toxic effects of Acephate in the tissue of Poecilia sphenops have been reported. The laboratory animal was treated with Acephate, the LC50 was found. The tissues were fixed in formalin for histopathological studies. The...