Antioxidant, Analgesic and Antipyretic Activities of Ethanol Extract of the Stem Bark Dichaetanthera africana (Hooker F.) Jacq. Felix. (Melastomataceae)
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 14, Issue 5
Abstract
Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities of the ethanol extract of the stem bark of Dichaetanthera africana. Place and Duration of Study: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, India, between September 2014 and November 2014. Methodology: Antioxidant activities were determined in vitro by the total phenolic, total flavonoid, ferric reducing antioxidant power (FRAP), DPPH, hydrogen peroxide and ABTS methods. Analgesic and antipyretic activities were investigated using the acetic acid induced writhing and brewer’s yeast induced hyperpyrexia assays respectively. Results: Ethanol extract had high phenolic (4.15-44.35 mgCA/g) and flavonoid (85.56-596.7 mgCA/g) contents and FRAP (187.87-371.41 mgCA/g). This extract exhibited strong DPPH (IC50 = 0.49 µg/ml), H2O2 (IC50 = 1.62 µg/ml) and ABTS (IC50= 0.43 µg/ml) radical scavenging activities. Significant reduction of abdominal writhing (P< 0.001) and fever (P< 0.001) were observed in rats in a dose dependent manner after administration of the ethanol extract with the most effective dose being 400 mg/kg b.w. Conclusion: These results provide promising baseline information for the potential use of Dichaetanthera africana in the treatment of pain and fever.
Authors and Affiliations
Aristide Laurel Mokale Kognou, Rajesh Singh Pawar, Rosalie Annie Ngono Ngane, Pradeep Pateriya, Prem Narayan Pal, Alembert Tiabou Tchinda, Gabriel Agbor Agbor, Rebecca Madeleine Ebelle Etame, Raymond Simplice Mouokeu, Albert Sone Mouelle, Cecile Enguehard Gueiffier
Keywords
Related Articles
- EP ID EP342314
- DOI 10.9734/BJPR/2016/31468
- Views 86
- Downloads 0
Evaluation of Phytochemical Profile and Haemolytic Activity of Acacia mearnsii
Acacia mearnsii is characterized as a tree with dark green leaves and grow on any types of soil. Its bipinnate leaves with individual leaflets that are used in folk medicine in wound healing, antioxidant, anti-inflammato...
Anti-Mycobacterium Metabolite from Marine Sponge Iricinia fusca
Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of...
Enhanced Growth-inhibitory Effect of Microemulsified Curcumin Formulation in Human Prostate Cancer LNCaP Cells
Aim: To assess the effect of curcumin microemulsified with non-ionic surfactant surfynol 465 W or dispersed using edible oils on prostate LNCaP cancer cell viability and glutathione status. Methodology: LNCaP cells were...
Barriers of Medication Adherence and Health Outcomes
Medication adherence is a worldwide health care problem. Medication adherence refers to whether patients take medication as prescribed by the healthcare provider. Increasing medication adherence may have a great impact o...
Efficacy and Safety of Reimbursed Orphan Medicines in Bulgaria – Systematic Review and Meta-analysis (Part I)
Background: To make reimbursement decisions for orphan medicines the regulators need robust evidences for their efficacy and safety provided by systematic reviews and meta-analyses. The goal of the current study is to e...