Antioxidant, Analgesic and Antipyretic Activities of Ethanol Extract of the Stem Bark Dichaetanthera africana (Hooker F.) Jacq. Felix. (Melastomataceae)
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 14, Issue 5
Abstract
Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities of the ethanol extract of the stem bark of Dichaetanthera africana. Place and Duration of Study: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, India, between September 2014 and November 2014. Methodology: Antioxidant activities were determined in vitro by the total phenolic, total flavonoid, ferric reducing antioxidant power (FRAP), DPPH, hydrogen peroxide and ABTS methods. Analgesic and antipyretic activities were investigated using the acetic acid induced writhing and brewer’s yeast induced hyperpyrexia assays respectively. Results: Ethanol extract had high phenolic (4.15-44.35 mgCA/g) and flavonoid (85.56-596.7 mgCA/g) contents and FRAP (187.87-371.41 mgCA/g). This extract exhibited strong DPPH (IC50 = 0.49 µg/ml), H2O2 (IC50 = 1.62 µg/ml) and ABTS (IC50= 0.43 µg/ml) radical scavenging activities. Significant reduction of abdominal writhing (P< 0.001) and fever (P< 0.001) were observed in rats in a dose dependent manner after administration of the ethanol extract with the most effective dose being 400 mg/kg b.w. Conclusion: These results provide promising baseline information for the potential use of Dichaetanthera africana in the treatment of pain and fever.
Authors and Affiliations
Aristide Laurel Mokale Kognou, Rajesh Singh Pawar, Rosalie Annie Ngono Ngane, Pradeep Pateriya, Prem Narayan Pal, Alembert Tiabou Tchinda, Gabriel Agbor Agbor, Rebecca Madeleine Ebelle Etame, Raymond Simplice Mouokeu, Albert Sone Mouelle, Cecile Enguehard Gueiffier
Keywords
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- EP ID EP342314
- DOI 10.9734/BJPR/2016/31468
- Views 99
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