ANTIOXIDANT AND ANTHELMINTIC POTENTIAL OF THE STEM & LEAVES OF WHITE ABRUS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Introduction: World Health Organization (WHO) appreciates the importance of medicinal plants for public health care in developing nations. White Abrus (Abrus precatorius Linn) have important role in traditional medicine, its seeds, bark, leaves and stem are medicinal.Objective: The potential of the leaves and stem of this plant as an antioxidant and anthelmintic agents were evaluated.Methods: All the analysis was done according to standard protocols.Results: The methanolic extract produced significant anthelmintic and antioxidant properties in a dose-dependent manner. DPPH free radical scavenging assay of leaf and stem exhibited IC 50 values of 275 ±0.83 μg/ml and 170 ± 0.90 μg/ml respectively. At 1000 μg/ml concentration both leaf and stem shows maximum radical scavenging activity (93 % & 98 %).Superoxide anion scavenging assay also resulted promising activity with IC 50 values 85± 0.83μg/ml and 80± 0.90μg/ml respectively for leaf and stem. The percentage scavenging of super oxide radical surged with the enhanced concentration of plant extracts. The maximum scavenging activity of plant extract was at 1000 μg/ml concentration, 80 % and 92% respectively in leaf and stem extracts.Preliminary phytochemical screening revealed the presence of saponins, steroids, flavonoids, terpenoids, cardiac glycosides and phenols in both stem and leaves that may be the reason for its biological properties.Conclusion: The findings of this study indicate that this plant is medicinal with prominent antioxidant and anthelmintic property.Â
Authors and Affiliations
Alby Alphons Baby, Regi Raphael K
Keywords
Related Articles
- EP ID EP579413
- DOI -
- Views 82
- Downloads 0
DESIGN AND EVALUATION OF BUCCOADHESIVE CONTROLLED RELEASE FORMULATIONS OF PROCHLORPERAZINE MALEATE
Objective: The Purpose of this work was to design mucoadhesive tablets of prochlorperazine maleate to release the drug in buccal cavity for an extended period of time in order to avoid the first-pass metabolism.Methods:...
ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF BAMBUSA BAMBOS DRUCE AGAINST POLOXAMER-407 INDUCED HYPERLIPIDEMIA IN RATS
Objective: The aim of present study was to investigate a dose-dependent antihyperlipidemic effect of methanolic extract of Bambusa bambos Druce. (Family: Graminae) (MEBB) in Poloxamer-407 induced hyperlipidemia in rats a...
DESIGN AND CHARACTERIZATION OF A NEW SUGAR FREE FORMULATION OF VITAMINS C, E, B6 AND MINERALS Zn2+ AND Mn2+ FOR CHILDREN IN ORAL VIAL WITH PLUNGER AND TEAR OFF CAP
Objective: Aim of present study was to provide a stable sugar free formulation that contains vitamins C, E, B6 and minerals Zn2+ and Mn2+ in a unique pharmaceutical dosage form which consists of a plunger containing gran...
FLOATING-BIOADHESIVE MATRIX TABLETS OF HYDRALAZINE HCL MADE OF CASHEW GUM AND HPMC K4M
Objective: The objective of this paper was to prepare and evaluate floating-bioadhesive cashew gum-hydroxypropyl methylcellulose (HPMC K4M) matrix tablets for the gastro-retentive release of hydralazine HCl.Methods: The...
COCONUT MILK MODULATE THE ANTIGENICITY OF ALPHA-LACTALBUMIN IN BALB/C MICE
Objective: The aim of this work was to study the biochemical characteristics of coconut milk and its antigenic effect on the Balb/c mice immunized with α-lactalbumin protein, as well as its consequences on the structure...