ANTIOXIDANT AND ANTIULCER ACTIVITY OF ABRUS PRECATORIUS LEAF EXTRACT AGAINST ACETIC ACID-INDUCED GASTRIC ULCER IN RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 7
Abstract
Objective: The present study deals with the study of antiulcer activity of Abrus precatorius leaf extract in acetic acid-induced gastric ulcers was studied in rats. Methods: In the present study, A. precatorius leaf extract was carried out in antiulcer activity against acetic acid-induced gastric ulcer in rats. A. precatorius at doses of 150 mg/kg and 300 mg/kg were administered orally once daily for 10 days. Results: It was found that extract significantly reduced ulcer index. The plant leaves made gastric anti-secretory effect by decreasing gastric volume and acidity. Then, gastric mucin was increased, which showed gastric cytoprotective effect. The plant showed the prevention effect of increased lipid peroxidation during ulceration by acetic acid. Activities of the antioxidant enzymes were enhanced during ulceration by this plant leaves. Conclusion: Leaves of A. precatorius Linn. could decrease acetic acid-induced gastric ulcers in rats and this antiulcerogenic activity was mediated through antioxidant defense mechanism.
Authors and Affiliations
LALITA NAGDA , CHANDRA PRAKASH JOSHI , JYOTI MENARIA
Keywords
Related Articles
- EP ID EP635664
- DOI -
- Views 115
- Downloads 0
RISK FACTORS FOR NON-COMMUNICABLE DISEASES AMONG RURAL ADOLESCENTS: A SCHOOL-BASED CROSS-SECTIONAL STUDY
 Objective: Non-communicable diseases (NCD) in recent times have attained a magnitude of epidemic proportion, with increasing number ofadolescence being reported as obese. The risk factors for NCD such as obesity, seden...
FORMULATION AND EVALUATION OF DOLUTEGRAVIR SODIUM SOLID DISPERSIONS AND FAST DISSOLVING TABLETS USING POLOXAMER-188 AND JACK FRUIT SEED STARCH AS EXCIPIENTS
Objective: The current work mainly focuses on solubility enhancement of dolutegravir which is a biopharmaceutical classification system Class-II drug using jack fruit seed starch (JFS2) as excipient which improves the dr...
FORMULATION AND EVALUATION OF IN VITRO TRANSDERMAL PATCH DICLOFENAC SODIUM USING CHITOSAN POLYMER AND POLYVINYL ALCOHOL CROSS-LINKED TRIPOLYPHOSPHATE SODIUM
Objective: The aim of this study was to investigate diclofenac sodium patches using chitosan (Ch) and polyvinyl (PVA) alcohol cross-linked tripolyphosphate sodium (TPP) to increased transdermal permeation of the drug fro...
INVESTIGATION OF CRITICAL MATERIAL ATTRIBUTES OF NANOCELLULOSE IN TABLETS
Objective: The present work aims to compare powder flow properties and post-compression characteristics of acid hydrolysis nanocellulose (AH-NC) a novel excipient with microcrystalline cellulose (MCC PH200) to demonstrat...
EVALUATION OF IN VITRO ANTIOXIDANT AND ANTIDIABETIC POTENTIALS OF DIFFERENT FRACTIONS OF MAYTENUS HEYNEANA ROOT EXTRACT
Objective: In an attempt to explore herbal drug which may become useful in the prevention of diabetes and antioxidant potential by the ethanol extracts of Maytenus heyneana (MH) root belonging to the family Celastraceae...