ANTIOXIDANT PROTECTION AND GLYCOPROTEINS COMPOSITION OF THE GASTRIC MUCOSA IN THE EXPERIMENTAL PATHOLOGY OF THE GASTRODUODENAL ZONE WITH THE USE OF L-ARGININE-L-GLUTAMATE
Journal Title: Наукові доповіді НУБіП України - Year 2018, Vol 4, Issue 4
Abstract
The prevalence and frequency of complications in the acid-dependent diseases group (gastroesophageal reflux disease, peptic ulcer disease) prompts researchers to further study the pathophysiological factors of these diseases and their correction.The purpose of the work is to investigate the state of antioxidant protection systems and muccinum carbohydrate components composition in rats with erosive-ulcer pathology of the gastroduodenal zone under the action of L-arginine-L-glutamate. The studies were carried out on white, non-breeding male rats weighing 220-250 g. The animals were divided into three groups. I - control group (n = 6) were rats injected intragastheally through a probe physiological solution. In group ІІ (n = 6) rats with erosive-ulcerous lesions (EUL) of the gastroduodenal zone (GDZ) entered. EUL modeling was carried out according to the following scheme: for 7 days, rats received injections of medical bile (1 ml / 100 g), together with immobilization and cold stresses for 1 hour at + 4 ° C, the following 7 days weren’t subjected to stressors and were kept in conditions of vivarium with a standard diet, with withdrawal from the experiment for the 14th day. For the 7th rats of the third group (n = 6), for 7 days EUL was modeled according to the scheme described, the following 7 days of the animals received intra-abdominal injections of L-arginine-L-glutamate (20 mg / 100 g), with an exclusion from the experiment in 14 days. At the conditions of stopping influence of exogenous ulcerogenic factors leading to the formation of the erosive-ulcerative pathology of the gastroduodenal zone, after one week in the tissue of the stomach, liver and blood of experimental rats intensification of lipoperoxidation processes with depletion of the glutathione system while simultaneously changing the composition of glycoproteins with increasing sialomuccinum were found. The use of L-arginine-L-glutamate resulted in the normalization of free radical processes, the level of reduced glutathione and the quantitative and qualitative composition of glycoproteins of the stomach. A possible mechanism that affects the muccinum qualitative composition is likely to be the interaction between the oxidative-reducing cell metabolites and the transcription factors regulating expression of the MUC genes. Further research should be directed on studying the molecular mechanisms of interaction between paths of redox systems and factors influencing the proliferation and differentiation of mucosal cells of the gastroduodenal zone.
Authors and Affiliations
L. A. Ponomarenko, O. A. Lykholat, O. M. Khomenko
Keywords
Related Articles
- EP ID EP386893
- DOI -
- Views 110
- Downloads 0
PHOTOSYNTHETIC ACTIVITY OF SEED WHEAT SOWS OF WINTER DEPENDENCE ON FERTILIZATION AND PROTECTION OF PLANTS UNDER THE CONDITIONS OF THE SOUTH OF UKRAINE
The article reflects the results of a study on the effect of fertilizers and plant protection on the photosynthetic activity of seed crops of winter wheat when grown in South Ukrainian. One of the most important elements...
FORECASTING OF EPIZOOTIC OF RABIES IN THE CHERNIHIV OBLAST ON THE BASIS OF GEOINFORMATION ANALYSIS
Here we report the results of monitoring the epizootic situation on rabies in Chernihiv oblast in 2017, analyze how it changed compared to the previous year. In 2017 there were 72 rabies cases in animals in Chernihiv obl...
DEVELOPMENT AND APPLICATION OF MACHINE EQUIPMENT FOR REARING PIGLETS UNDER CONDITIONS OF INDUSTRIAL TECHNOLOGY
In the article it is presented the results of the development and application of new technical means and the machine equipment intended for housing and feeding sows with offspring. The expansion of production volumes is...
DYNAMICS OF THE NOURISHING REGIME SOILS AT DIFFERENT SYSTEMS OF BASIC TREATMENT OF SOIL AND FERTILIZERS IN CROP ROTATION ON IRRIGATION
In the article are represented research results on the study of influencing of basic treatment of soil and fertilizers on the dynamics of the nourishing mode of soil. It was the purpose of researches to set influence of...
RESULTS OF ANALYSIS OF COLLECTION SAMPLES AND HYBRIDS F1 OF WINTER WHEAT FOR RESISTANCE TO LEAF RUST
In 2013-2016, 78 collectable samples of winter bread wheat were examined to identifying effective and stable sources of resistance to leaf rust and a degree of phenotypic dominance was identified in 39 first-generation h...