Antioxidant system activity in liver and guerin’s carcinoma of rats under conditions of ω-3 polyunsaturated fatty acids administration
Journal Title: Naukovyi visnyk Chernivetskoho universytetu. Biolohiia (Biolohichni systemy) - Year 2015, Vol 7, Issue 2
Abstract
The effect of ω-3 polyunsaturated fatty acids (PUFAs) supplementation on superoxide dismutase аnd catalase activities as well as the level of alpha-tocopherol and ascorbate were monitored in mitochondrial fraction of rat liver and Guerin’s carcinoma. It was shown that ω-3 PUFAs administration resulted in an increased activity of antioxidant enzymes and the level of alpha-tocopherol and ascorbate in hepatic mitochondria fraction of rats with tumor during the logarithmic phase of tumor growth. ω-3 PUFAs supplementation before and after transplantation of Guerin’s carcinoma resulted in the decrease of superoxide dismutase and catalase activity and the content of alpha-tocopherol and ascorbate in Guerin’s carcinoma mitochondrial fraction in the logarithmic phases of oncogenesis.
Authors and Affiliations
О. Кеца, І. Шмараков, М. Марченко
Keywords
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