ANTIPLASMODIAL ACTIVITY OF THE ETHANOL LEAF EXTRACT OF NEWBOULDIA LAEVIS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 4
Abstract
Malaria is a parasitic protozoan disease caused by the protozoan parasites belonging to the genus Plasmodium. It is a major threat to health and constitutes medical and developmental challenge to individuals, communities and nations. Newbouldia laevis is an ethno-medicinal plant widely used in the treatment of malaria and other ailments. Phytochemical screening and antiplasmodial studies were carried out on the crude and fractions of the leaf extract of the plant using standard procedures. The phytochemical screening revealed the presence of alkaloids, saponins, glycosides, tannins, terpenes, flavonoids and carbohydrates in varying proportions. The crude extract exhibited a dose-dependent antiplasmodial activity against the parasite on all the models. The fractions also exhibited antiplasmodial activities with the ethyl acetate fraction showing the best antiplasmodial activity which is comparable to the standard drug. From the results obtained, Newbouldia laevis leaf is a good source of phytochemicals and also a potential source of potent antiplasplasmodial compounds that could be developed into drugs useful for the treatment of malaria.
Authors and Affiliations
Arnold C. Igboasoiyi
Keywords
Related Articles
- EP ID EP618024
- DOI -
- Views 184
- Downloads 0
THE PREVALENCE OF SELF-MEDICATION AND ITS ASSOCIATED FACTORS IN PAKISTAN
Background: The aim and objective of the study was to identify the prevalence of self-medication practices among individuals. Methods: Hundred pre-designed questionnaires were filled by the people. The questionnaire cont...
ISOLATION AND CHARACTERIZATION OF ENDOPHYTIC AND RHIZOPHERIC BACTERIA ASSOCIATED SWEET-POTATO PLANTS CULTIVATED ON SOILS OF THE MEKONG DELTA, VIETNAM
Rhizobacteria and endophytic bacteria in the acid sulphate rhizosphere soils and stems/roots of sweet potatoesgrown on acid-sulphate soilsof the Mekong Delta, Vietnam were studied. A total of 96isolates were isolated on...
HOW FAMILY HISTORY OF THE DISEASE AFFECTS KAP REGARDING BREAST CANCER AND ITS SCREENING METHODS
Pakistan has one of the highest incidence rates of breast cancer in Asia. Breast cancer is a major contributor towards cancer related mortality and morbidity in Pakistani women. The study aimed to examine the effects of...
CURRENT TRENDS ON TRANSDERMAL DRUG DELIVERY SYSTEM: OPTIMIZATION, FORMULATION, DEVELOPMENT, AND EVALUATION: AN OVERVIEW
Transdermal drug delivery system can deliver the drugs through the skin portal to systemic circulation at a predetermined rate and maintain clinically the effective concentrations over a prolonged period of time. Transde...
DIOCTAHEDRAL SMECTITE API' ANALYTICAL METHOD DEVELOPMENT AND VALIDATION ON TITRIMETRIC METHOD FOR THE QUANTITATIVE AND QUALITATIVE DETERMINATION OF IN ORAL DOSAGE FORM.
Back Ground[1]: The Dioctahedral Smectite belonging to a Smectite group (derived from the Greek, smectos, which means soap) indicates large chemical inconsistency, consequential in many detailed mineral names (Gwyn 1988)...