Antiproliferative effects of Origanum syriacum L. and Myrtus communis L. on human colon cancer cell line
Journal Title: Proceedings of the International Conference on Advanced Materials and Systems (ICAMS) - Year 2018, Vol 1, Issue
Abstract
In this study, we aimed to investigate the composition and antiproliferative efficacy of Origanum syriacum L. and Myrtus communis L. essential oils on the HCT cell line. Also, it was aimed to search the synergistic activities of Origanum syriacum L. and Myrtus communis essential oils with MTX (Methotrexate) on HCT 116 cells. The main essential oil components of Origanum syriacum L. were Thymol (42,18%), Carvacrol (33,95%), Cymene (8,87%), γ-Terpinene (8,21%) and for Myrtus communis L. the main essential oil components were Eucalyptol (45,41%), α-Pinene (20,86%), Linalool (9,71%). In this study, HCT 116 human colon cancer cell line and Vero cell line were used. To determine the non-cytotoxic concentration of Origanum syriacum L. and Myrtus communis L. essential oils Vero cell line was selected. The cytotoxic activity of the essential oils was measured using the MTT method and the results were evaluated as IC50. The Inhibition concentrations of the essential oils of Origanum syriacum L. and Myrtus communis L. essential oils against cancer HCT 116 and Vero cells were evaluated. It has been found that the essential oils of the Origanum syriacum L. and Myrtus communis have an important antiproliferative effect on human colon cancer cells. In our study findings, we think that these two plant essential oils may be a potent drug active compound for cancer treatment.
Authors and Affiliations
Şevket Öztürk, Nizami Duran
Keywords
Related Articles
- EP ID EP602589
- DOI 10.24264/icams-2018.IV.3
- Views 120
- Downloads 0
Graphene oxide and metal particles nanocomposites for inhibition of pathogenic bacteria strains
The most effective means to protect against bacterial invasion and to reduce the risk of dangerous infections are antibacterial components synthesis. Preliminary investigations show that hybrid coatings of graphene oxide...
Aspects regarding accomplishing multilayered filtration media, using electrospun webs
Filtration media are widely used in industry in various forms for the filtration and removal of particles from fluids. Filtration media represented by the non-woven fibrous materials with the fibers disposed close enough...
Dynamic vulcanized thermoplastic elastomers based on ethylene-propylene terpolymer and polyethylene
The paper presents the studies on the obtaining and characterization of new types of dynamically vulcanized thermoplastic elastomers based on ethylene-propylene terpolymer rubber and polyethylene. As a vulcanizing agent,...
Diclofenac spongious matrices based on collagen and alginate for relieving injury pains
The sport injuries become more and more frequent so there is a need to discover new solutions for increasing the quality of life for people affected by such wounds. The aim of this study was to obtain a novel NSAID drug...
Antibacterial and UV protective effects of cotton fabrics dyed with Reseda luteola extract
Reseda luteola (Weld) extracts were used to dye textiles and decorate medieval manuscripts. The main components are luteolin and apigenin in the form of β-glucosides, having an important role in plant UV protection, colo...