Antispasmodic activity of Calotropis Procera leaf extract - An invitro study in rat colon
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 2
Abstract
Calotropis procera has number of medicinal importance as it contains a number of active constituents like cardiac glycosides, terpenes, tannins flavinoids etc. it has also been found to have antispasmodic property. Therefore the present work was undertaken to evaluate the antispasmodic effect on different isolated tissues. Invitro models: isolated rat colon by using bioassay techniques.In contrast to the findings of c.procera ethnolic extract on rat colon produced antispasmodic effect on the gastrointestinal smooth muscles. Invitro studies of rat colon the ethnolic extract of c.procera leaves of 10 mg/ml was added individually and along with acetylcholine,5-HT and carbachol produced contraction was inhibited by this crude extract(30%, 31%, 81.56%, .89.54% 82%, and 56.25%, 25.71%, 30.43%, 53.84%).hence extract showed excellent antispasmodic activity.
Authors and Affiliations
Jagadeesh K Jagadeesh K,
Keywords
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