Antitrypanosomal Activity of Allium porrum Ethyl Acetate Bulb Extract in Trypanosoma brucei brucei Experimentally Infected Wister Albino Rats
Journal Title: European Journal of Medicinal Plants - Year 2017, Vol 19, Issue 4
Abstract
Aims: The present study investigated the antitrypanosomal activity of crude ethyl acetate bulb extracts of A. porrum plant against T. b. brucei. Methodology: Twenty five male albino rats were divided into five groups and infected with x106/ml of T. b. brucei. Group 1 was infected and untreated while groups 2-4 were infected and treated with single intraperitoneal injection 50, 75 and 100 mg/kg of ethyl acetate extract of A. porrum while a single dose 3.5 mg/kg diaminazene aceturate was administered to group 5 when parasitaemia was established at x106 day 5 post infection. Results: Clinical manifestations of trypanosomoses such as increased rectal temperature, weakness and dullness were observed in experimental rats in all the groups. There was decrease packed cell volume (PCV) and red blood cell count (RBC) in group 1-4 which was not significant (p>0.05) while group 5 had a significant increase (p<0.05) in PCV and non-significant increase (p>0.05) in RBC post treatment. There were feeble changes in the pre-treatment and post-treatment parasitemia level in the groups treated with ethyl acetate extract of A. porrum while there was significant clearance in parasitemia in the control group. Conclusion: Interperitoneal injection of ethyl acetate extracts of A. porrum at the dose and concentration used in this study, has trypanosomal reduction activity in wister rats.
Authors and Affiliations
S. Odeyemi Omonike, A. Umar Yahaya, M. S. Abdulsalami
Keywords
Related Articles
- EP ID EP327230
- DOI 10.9734/EJMP/2017/34418
- Views 121
- Downloads 0
The Hypoglycemia Effect of Alkaloid Compounds from Oil Free Mahagony Seeds (Swietenia macrophylla, King)
Aim: To study the hypoglycemia effect of alkaloid compounds (Alkaloid crude extract) from oil free mahagony seeds (Swietenia macrophylla, King). Study Design: Experiments of alkaloid compounds isolation and in vivo test...
Antioxidant and in vivo Wound Healing Activities of Clausena anisata
Leaves of Clausena anisata are used in many parts of West Africa including Ghana for management of wounds and other skin infections. The study was to evaluate the in vivo wound healing and antioxidant properties of ethan...
Evaluation of Antimicrobial Activity of Mentha piperita, Tragia involucrata (L) and Urtica massaica Used as Medicinal Plants in Tanzania
Aims: To evaluate antimicrobial activity of Mentha piperita, Tragia involucrata (L) and Urtica massaica used as medicinal plants in Tanzania. Study Design: Experimental study was carried out by using 96 wells micro dilut...
Isolation and Characterization of Flavonoids in Urena lobata Leaves
Aim: Urena lobata L. a member of Malvaceae family, is widely used as famine food in Africa. It is also used in traditional medicine system to cure gonorrhea, fever, wounds, toothache & rheumatism. The plant has already b...
In vivo Antiplasmodial Activity and GCMS Analysis of Vernonia colorata (Willd) Drake Leaf
Aim: To analyse the phytochemical components using GCMS technique and evaluate the antiplasmodial activity of crude extract and partitioned fractions of Vernonia colorata leaf. Study Design: Qualitative, gravimetric an...