ANTIULCER ACTIVITY OF ROOTS OF ZAPOTECA PORTORICENSIS (FAM. FABIACEAE)
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2010, Vol 1, Issue 3
Abstract
Background: The roots of Zapoteca portricensis is a common remedy in the treatment gastrointestinal disorders used by tradomedical practitioners in Eastern Nigeria. Aim: This study was aimed at evaluating the possible antiulcer activity of the root of this plant in experimental rats. Methods: A methanolic root extract was prepared by cold maceration. Antiulcer activity was tested using absolute ethanol and indomethacin induced ulcer models. Sucralfate(100 mg/kg oral) was used as the reference drug. Different groups of albino rats of male sex were given three doses (50, 100, 200 mg/kg) of the extract. Phytochemical analysis of the freshly dried roots was also done. Results: Phytochemical results revealed presence of alkaloids, terpenoids, glycosides and flavonoids. The ethanol model produced an average ulceration in rats with reduction of ulcer (50%, 75% and 90%) seen in all the extract treatment. A dose dependent inhibition of ulcer was seen in all doses of the extract with doses 100 and 200mg/kg produced a significant reduction compared with control. In the indomethacin model, an absolute ulceration was produced in all the animals. Inhibition of ulcer(57.1%, 65.7% and 80.0%) was seen in the treatments with the extracts in a dose dependent manner. All the three doses of the extracts produced significant ulcer protection compared with control. Conclusion: This study has shown that roots of this plant (Zapoteca portoricensis)
Authors and Affiliations
Okonkwo. J, Adibe O, Ubaka. M, Ukwe. V, Akah A
Keywords
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