ANTIULCEROGENIC EFFICACY OF ETHANOLIC EXTRACT OF VITIS VINIFERA LEAVES IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 9
Abstract
Objective: The ethanolic extract of Vitis vinifera leaves (VVE) (500 mg/kg body weight), ranitidine (50 mg/kg body weight) and both of them were tested for their gastroprotective and curative effects against the incidence of peptic ulcer. Methods: The antiulcer effects of VVE were investigated using a combination of indomethacin and cold-stress for 2h. To ascertain the mechanism of action of VVE, its protective and curative effects were studied on gastric volume, gastric juice acidity, ulcer index and malondialdehyde (MDA), glutathione (GSH), catalase (CAT), glutathione–S-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO) activities of both stomach and duodenum of rats. Moreover, histopathological effects on stomach and duodenum were determined.Results: The antioxidant activity of VVE was demonstrated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) test. VVE was found to reduce the ulcer index, gastric volume and the level of gastric juice acidity. Also, VVE showed gastroprotective and curative activities mainly through improvement of antioxidant status and decreasing lipid peroxidation accompanied with amelioration of both stomach and duodenum architectures.Conclusion: The prophylactic and curative effects of VVE proved to be effective in preventing gastric and duodenal ulceration which may be probably due to its antioxidant and anti-acid secretory effects.
Authors and Affiliations
Dawlat A. Sayed, Sohair R. Fahmy, Amel M. Soliman, Nagat S. Hussein
Keywords
Related Articles
- EP ID EP576028
- DOI 10.22159/ijpps.2016v8i9.12846
- Views 60
- Downloads 0
FORMULATION, OPTIMIZATION AND IN VITRO EVALUATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF FUROSEMIDE
Objective: The objective of this study was to formulate and evaluate sustained release gastro retentive microspheres of furosemide using mucoadhesive polymers. It was expected that gastro retention plus mucoadhesion woul...
SURVEY ON HOW ANTIBIOTICS ARE DISPENSED IN COMMUNITY PHARMACIES IN ALBANIA
Objective: To evaluate pharmacists’ tendency to dispense antibiotics without prescription.Methods: A random survey was conducted for this study. Statistical analyses were made with Open Epi. Research group personnel we...
GENETIC DIVERSITY ASSESSED THROUGH RAPD MARKERS IN SYZYGIUM ALTERNIFOLIUM (WT) WALP
Objective: The present study has been carried out to evaluate the genetic diversity in a representative population of Syzigium alternifolium from six different accessions of chittoor district.Methods: Genomic DNA isolati...
A FAST AND SENSITIVE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF HYDRAZINE IN ATAZANAVIR SULFATE DRUG SUBSTANCE
Objective: To develop a fast and sensitive UV spectrophotometric method for the quantitative estimation of Hydrazine in Atazanavir Sulfate drug substances and validate as per ICH guidelines.Methods: The method was based...
COMPRESSIONAL PROPERTIES OF METRONIDAZOLE TABLET FORMULATIONS CONTAINING ALOE VERA AS BINDING AGENT
The purpose of the present work was to determine the compressional characteristics of metronidazole tablet containing Aloe vera as a binding agent. Metronidazole tablet formulations were prepared using Aloe vera mucilage...