Antiviral activities of Cucumis metuliferus fruits alkaloids on Infectious Bursal Disease Virus (IBDV)
Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 2
Abstract
Objective: The toxicity of the alkaloids isolated from the fruit pulp of Cucumis metuliferus was investigated in chicken fibroblast cells. Materials and Methods: The alkaloids from C. metuliferus fruit pulp were isolated and their effects assayed on infectious bursal disease virus (IBDV) using chicken ebryo fibroblast cells. Results: There was no observed structural change on the chicken fibroblast cells when exposed to concentrations of 0.195 and 100 mg/ml of the alkaloids; and there was observed antiviral activities on IBDV at concentration between 6.125 and 100 mg/ml, while concentrations of the alkaloids between 0.195 to 3.125 mg/ml showed no antiviral activities compared to the control. Conclusion: The alkaloid showed good margin of safety on chicken fibroblast cells, with antiviral activities on infectious bursal disease virus (IBDV).
Authors and Affiliations
Anne A. Anyanwu, Nanloh S. Jimam, Simeon Omale, Noel N. Wannang
Keywords
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