Anxiolytic effect of noscapine in mice.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 4
Abstract
The anxiety-related effects of noscapine were investigated using male Balb-c mice. Since noscapine-induced locomotion may alter the animals' activity level in the dark-light model, the anxiety-related effects of noscapine were studied at doses with no effect on locomotion (0.1, 0.2, 0.3, 0.4, 0.5, 0.8, 1, 1.5 and 2 mg/kg). The parameter measured in dark-light model was the time spent in lit compartment. Intraperitoneal administration of noscapine (0.1-0.5 mg/kg) did not produce a significant effect on the time spent in the light, whereas higher doses (0.8, 1, 1.5 and 2 mg/kg) increased it significantly, implying an anxiolytic effect.
Authors and Affiliations
Parvin Khodarahmi, Armin Rashidi, Iman Khodarahmi
Keywords
Related Articles
- EP ID EP154628
- DOI -
- Views 95
- Downloads 0
Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level.
N-feruloylserotonin (N-f-5HT) isomers, isolated from seeds of Leuzea carthamoides (Wild) DC, inhibited dose-dependent oxidative burst in human whole blood and isolated neutrophils in vitro, which were measured by luminol...
Role of nitric oxide, nitroxidative and oxidative stress in wound healing.
Redox-regulated processes are relevant to wound healing. A balance between bioavailable nitric oxide (NO) concentration and a level of oxidative and nitroxidative stress in wounds may be crucial in wound repair. The high...
Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin.
The purpose of this study was to investigate the possible effects of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, simvastatin, on the pharmacokinetics of diltiazem and its main metabolite, desacetyldil...
Scavenging and antioxidant potential of physiological taurine concentrations against different reactive oxygen/nitrogen species.
While several studies have been conducted on the antioxidant properties of the beta-amino acid taurine, these studies all used concentrations lower than what is found physiologically. This study investigates the scavengi...
Effect of pregnancy and tobacco smoke on the antioxidant activity of rutin in an animal model.
Tobacco smoke is a source of free radicals and causes oxidative stress in smokers' tissues. The aim of the current study was to evaluate the effect of rutin on the total antioxidant status (TAS) in pregnant and non-pregn...