Application and safety of methotrexate in ophthalmology
Journal Title: Eye Science (Yanke Xuebao) - Year 2023, Vol 38, Issue 7
Abstract
Methotrexate (MTX) is a folate analog with anti-proliferative, anti-inflammatory and immunomodulatory effects. It is widely used in clinical practice to treat various diseases, including malignant tumors and autoimmune diseases. MTX is used for treating eye diseases by local injection or whole-body administration. Its safety and efficacy have been confirmed. The intravitreal injection can reduce the whole-body use of glucocorticoids and immunosuppressive agents, so it is applied in ophthalmology increasingly. The specificity of MTX has been found in its application in special patients, such as men and women in pregnancy preparation period, pregnant women, lactating women, children, adolescents and the elderly. The dosage varies from patient to patient. Common adverse reactions to low-dose MTX include gastrointestinal symptoms, liver dysfunction, etc. Serious adverse reactions are relatively rare, but pharmaceutical monitoring is still necessarily needed. This review summaries the usage and adverse reactions of MTX in clinical practice, to provide reference for its application in clinical practice in ophthalmology.
Authors and Affiliations
Qi GUO, Wenyu WU, Zeli GUO, Yandong WANG
Keywords
Related Articles
- EP ID EP764660
- DOI 10.12419/2305190001
- Views 14
- Downloads 0
Measurement of corneal thickness in myopia with Corvis ST corneal biomechanical analyzer
[Objective:] To compare the differences of corneal thickness measured by corneal biomechanical analyzer (Corvis ST), A-mode ultrasonic thickness meter (A-ultrasound) and Lenstar LS 900 (Lenstar) in myopia, so as to provi...
Development and application of multi-modal anterior eye imaging system
[Objective:] To obtain the comprehensive information of the anterior eye image, establish complementary information for the diagnosis and evaluation of ocular diseases. [Methods:] We developed a multi-modal, non-invasive...
Analysis of disease spectrum and epidemiology of inpatients with neuroophthalmic disease from single center
[Objective:] To analyze the spectrum and epidemiological characteristics of neuro-ophthalmic diseases from single center, and to provide basis for guiding the diagnosis and treatment of neuro-ophthalmic diseases. [Method...
Common quality problems in ophthalmic clinical trials
In this paper, a retrospective analysis method was used to count 58 clinical trials conducted by Zhongshan Ophthalmic Center from January 2015 to April 2020, and common quality problems were found in quality control. The...
An investigative study of critical thinking abilities among Masters' degree postgraduates in ophthalmology
[Objective:] To investigate the current situation of critical thinking abilities of masters’ degree postgraduates in ophthalmology and identify the factors affecting the critical thinking abilities. [Methods:] Using the...