APPLICATION OF CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY FOR OPTIMIZATION OF METAL ORGANIC FRAMEWORK: NOVEL CARRIER FOR DRUG DELIVERY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 8
Abstract
Objective: The aim of the present study is to optimize the synthesis method of metal-organic framework (MOF) for high yield and larger surface area with minimum size for efficient drug loading. Materials and Methods: Materials of Institute Lavoisier (MIL)-101-NH2 was synthesized by microwave-assisted hydrothermal method. Central composite design (CCD) under response surface methodology (RSM) was used for optimization. Process optimization was done by validating the model to obtain maximum surface area, maximum yield, and minimum particle size. Final obtained formulation was characterized by particle size and zeta potential, scanning electron microscopy, powder X-ray diffraction, Fourier-transform infrared spectroscopy, Brunauer–Emmett–Teller, and thermogravimetric analysis. Furthermore, gemcitabine (GEM) was used as a model drug for encapsulation in these MOFs for drug delivery carriers. Results: The results revealed that MIL-101-NH2 of average size-158 nm with high yield (70%) and high surface area (2347 m2/g) could be produced easily and reproducibly at a selected condition. This enhances the drug delivery application of the valuable MIL-101-NH2. Optimized values for these parameters were 170°C, 5.00, and 1:1:400 for temperature, pH, and reactant ratio, respectively. MIL-101-NH2 appeared as a promising carrier for GEM delivery with higher encapsulation (77.7±2%) and loading (22.6±2%). Conclusion: The results conclude that processing parameters such as temperature pH and reactant concentration obtained from CCD-RSM significantly affect the main constraints, i.e., surface area, particle size, and yield. The faster encapsulation of GEM in MOF makes them a promising carrier for drug delivery application.
Authors and Affiliations
PREETI KUSH , JITENDER MADAN , PARVEEN KUMAR
Keywords
Related Articles
- EP ID EP636145
- DOI -
- Views 121
- Downloads 0
The CURRENT TRENDS AND TREATMENTS IN DIABETIC RETINOPATHY
The drastically increasing issues of the disease scenario currently are with different types of diabetes all over the world. It has been reported, approximately 592 million are suffering from the disease throughout the w...
THE PROTECTIVE EFFECTS OF ECHINOPS HETEROPHYLLUS AQUEOUS EXTRACT AGAINST METHOTREXATE-INDUCED HEPATOTOXICITY IN RABBITS
Objective: The aim of this study was to investigate antioxidant and hepatoprotective properties of Iraqi Echinops heterophyllus aqueous crude extract and its flavonoid fraction against methotrexate (MTX)-induced hepatoto...
PHARMACOLOGICAL ACTIVITY OF ULVA LACTUCA POLYPHENOLS FRACTION: CARDIOPROTECTIVE AND ANTIOXIDANT ACTIVITIES AGAINST ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN RATS
Objective: The objective of this study is to assess the activity of Ulva lactuca polyphenols fraction in protecting the myocardial infarction induced by a high dose of isoproterenol. Methods: This study was carried out...
COMPARATIVE INVESTIGATION OF TOTAL ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITIES OF TWO ALLIUM SPECIES
ABSTRACTObjective: The main intention of this study was to assess the comparative free radical scavenging and total antioxidant capacities (TAC) of freshAllium sativum (garlic) bulbs and Allium cepa cultivar (green onion...
VANILLIN EXTRACTED FROM PROSO MILLET AND BARNYARD MILLET INDUCE APOPTOSIS IN HT-29 AND MCF-7 CELL LINE THROUGH MITOCHONDRIA MEDIATED PATHWAY
Objective: The main aim of the study was to investigate the bioactive compound vanillin extracted from proso millet (compound 1), and barnyard millet (compound 2) induces apoptotic cell death and whether it is mediated t...