APPLICATION OF MAGNESIUM DRUGS AND THEIR INFLUENCE ON THE INDICATORS OF CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH VARICOSE VEINS
Journal Title: Novosti Khirurgii - Year 2018, Vol 26, Issue 1
Abstract
Objective. To study the effect of magnesium drugs on the concentration of matrix metalloproteinases and magnesium ions in patients with varicose veins of the lower extremities. Methods. The study included 124 patients with varicose veins of the lower extremities, C2-C6, which were divided into 4 groups. In the 1 st group, surgical treatment followed with the administering the standard conservative treatment (32 patient); in the 2 nd group after the operation in addition to conservative treatment, magnesium drugs (32 patient) were prescribed; in the 3 rd group, conservative treatment without surgery (30 patient) was performed; in the 4 th group patients received standard conservative treatment and magnesium drugs (30 patient). The 5 th control group consisted of 20 healthy volunteers who did not suffer from varicose veins disease. Patients of groups 2 and 4 were given magnesium orotate 500 mg 2 tablets 3 times a day for 3 months. The content of serum matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) was determined by quantitative solid-phase enzyme immunoassay. The magnesium ion concentration was determined by colorimetric method. Results. In patients with varicose veins of lower extremities a significantly lower level of magnesium was registered compared to healthy volunteers not suffering from varicose veins: 35.5% of those with varicose veins had a magnesium deficiency, while only 15% had a decrease in this indicator among healthy volunteers. Against the background of additional therapy with magnesium drugs, there was a decrease in the number of patients with magnesium deficiency in groups with varicose veins of lower extremities, a decrease in MMP-9 concentration and an increase in TIMP-1 activity was also established. Conclusions. This study has confirmed the efficacy of magnesium drugs which have a pronounced effect on collagen degradation processes and extracellular matrix, reduce the activity of MMP-9, increase the concentration of TIMP-1, thereby affecting the MMP/TIMP balance in patients with varicose veins of lower extremities.
Authors and Affiliations
R. E. KALININ, I. A. SUCHKOV, A. S. PSHENNIKOV, A. A. KAMAEV, S. A. ISAKOV, A. N. RYABKOV
Keywords
Related Articles
- EP ID EP535902
- DOI 10.18484/2305-0047.2018.1.51
- Views 112
- Downloads 0
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