Application of next generation sequencing to detect targetable mutations: A case report of good response to everolimus in salivary duct carcinoma
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 4
Abstract
Salivary gland tumors are rare set of cancers accounting for less than 5% of all head and neck cancers. Of the various histologies salivary duct carcinomas are aggressive tumors with no standard of care management protocol. Several phase 1 and phase 2 studies of systemic therapy and targeted therapy in these tumors show minimal response rate. We present a case of metastatic salivary duct carcinoma, in whom next generation sequencing detected a targetable mutation in AKT1 gene and was started on everolimus with a stable disease over next 5 months.
Authors and Affiliations
Dr. Udip Maheshwari, Dr. Venkata Pradeep Babu Koyyala, Dr. Sumit Goyal, Dr. Sajjan Rajpurohit Singh, Dr. Manish Sharma, Dr. Ankush Jajodia
Keywords
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